2013
Vessel Wall Magnetic Resonance Imaging Identifies the Site of Rupture in Patients With Multiple Intracranial AneurysmsProof of Principle
Matouk CC, Mandell DM, Günel M, Bulsara KR, Malhotra A, Hebert R, Johnson MH, Mikulis DJ, Minja FJ. Vessel Wall Magnetic Resonance Imaging Identifies the Site of Rupture in Patients With Multiple Intracranial AneurysmsProof of Principle. Neurosurgery 2013, 72: 492-496. PMID: 23151622, DOI: 10.1227/neu.0b013e31827d1012.Peer-Reviewed Original ResearchConceptsAneurysmal subarachnoid hemorrhageSite of ruptureSubarachnoid hemorrhageMultiple intracranial aneurysmsMR-VWIHigh-resolution magnetic resonance vessel wall imagingIntracranial aneurysmsSteno-occlusive cerebrovascular diseaseVessel wall magnetic resonance imagingMR imaging findingsVessel wall enhancementMagnetic resonance vessel wall imagingMagnetic resonance imagingVessel wall imagingDefinitive treatmentCerebrovascular diseaseImaging findingsMedical recordsRuptured aneurysmsUnruptured aneurysmsPatientsAneurysmsWall enhancementResonance imagingRupture
2012
Intracranial Aneurysm Risk Locus 5q23.2 Is Associated with Elevated Systolic Blood Pressure
Gaál EI, Salo P, Kristiansson K, Rehnström K, Kettunen J, Sarin AP, Niemelä M, Jula A, Raitakari OT, Lehtimäki T, Eriksson JG, Widen E, Günel M, Kurki M, von und zu Fraunberg M, Jääskeläinen JE, Hernesniemi J, Järvelin MR, Pouta A, , Newton-Cheh C, Salomaa V, Palotie A, Perola M. Intracranial Aneurysm Risk Locus 5q23.2 Is Associated with Elevated Systolic Blood Pressure. PLOS Genetics 2012, 8: e1002563. PMID: 22438818, PMCID: PMC3305343, DOI: 10.1371/journal.pgen.1002563.Peer-Reviewed Original ResearchMeSH KeywordsAdultBlood PressureChromosomes, Human, Pair 5Cohort StudiesFemaleFinlandGenetic Predisposition to DiseaseGenome-Wide Association StudyHumansIntracranial AneurysmMaleMiddle AgedMuscle ProteinsMyocytes, Smooth MusclePolymorphism, Single NucleotideRisk FactorsTranscription FactorsZinc FingersConceptsSystolic blood pressureBlood pressureSystolic BPRisk factorsIntracranial aneurysmsElevated systolic blood pressurePopulation-based Finnish cohortsDiastolic blood pressureHigher systolic BPMean arterial pressureTraditional risk factorsVascular smooth muscle cellsStrong risk factorCommon risk factorsQuantitative outcome variablesVascular wall structureSmooth muscle cellsGenome-wide association studiesArterial pressureCerebral arteryPulse pressureFinnish cohortComplex diseasesMuscle cellsRisk alleles
2010
Long-term Angiographic and Clinical Outcomes in Completely Versus Incompletely Coiled Ruptured Intracranial Aneurysms: 912
Yilmaz S, Bijlenga P, Rashid M, Collot-Teixeira S, Brocheton J, Proust C, Rotival M, Risselada R, Summers P, Blasco J, Singh J, Waterworth A, Ebeling C, Friedrich C, Frangi A, Macho J, Byrne J, Sturkenboom M, Schaller K, Cambien F, Gunel M, McGregor J. Long-term Angiographic and Clinical Outcomes in Completely Versus Incompletely Coiled Ruptured Intracranial Aneurysms: 912. Neurosurgery 2010, 67: 540-540. DOI: 10.1227/01.neu.0000386985.32689.26.Peer-Reviewed Original Research
2007
GENETICS OF INTRACRANIAL ANEURYSMS
Nahed BV, Bydon M, Ozturk AK, Bilguvar K, Bayrakli F, Gunel M. GENETICS OF INTRACRANIAL ANEURYSMS. Neurosurgery 2007, 60: 213-226. PMID: 17290171, DOI: 10.1227/01.neu.0000249270.18698.bb.Peer-Reviewed Original ResearchConceptsIntracranial aneurysmsRisk factorsPatient-specific risk factorsGenetic susceptibilityAneurysmal subarachnoid hemorrhageHigh-risk individualsSpecific risk factorsIA pathogenesisNovel therapeutic strategiesRupture of aneurysmsDiagnosis of IAAsymptomatic patientsMedical comorbiditiesFormation of IAsPoor prognosisSubarachnoid hemorrhageEarly diagnosisEpidemiological studiesTherapeutic strategiesPreclinical settingDisease pathophysiologyOverall outcomePatientsAneurysmsModest improvement
2005
Hypertension, age, and location predict rupture of small intracranial aneurysms.
Nahed BV, DiLuna ML, Morgan T, Ocal E, Hawkins AA, Ozduman K, Kahle KT, Chamberlain A, Amar AP, Gunel M. Hypertension, age, and location predict rupture of small intracranial aneurysms. Neurosurgery 2005, 57: 676-83; discussion 676-83. PMID: 16239879, DOI: 10.1227/01.neu.0000175549.96530.59.Peer-Reviewed Original ResearchConceptsUnruptured intracranial aneurysmsRisk factorsIntracranial aneurysmsSubarachnoid hemorrhageUnruptured aneurysmsMinimal long-term morbidityHistory of hypertensionNormal blood pressureLong-term morbidityTertiary medical centerAge of patientsAnterior circulation aneurysmsPosterior circulation aneurysmsSignificant risk factorsSignificant independent predictorsRupture of IAsMortality of treatmentLogistic regression modelsSmall intracranial aneurysmsHypertensive patientsIndependent predictorsPosterior circulationBlood pressureAneurysm characteristicsCurrent guidelines