2012
Learning and Memory Depend on Fibroblast Growth Factor Receptor 2 Functioning in Hippocampus
Stevens HE, Jiang GY, Schwartz ML, Vaccarino FM. Learning and Memory Depend on Fibroblast Growth Factor Receptor 2 Functioning in Hippocampus. Biological Psychiatry 2012, 71: 1090-1098. PMID: 22541947, PMCID: PMC3371339, DOI: 10.1016/j.biopsych.2012.03.013.Peer-Reviewed Original ResearchMeSH KeywordsAnalysis of VarianceAnimalsBehavior, AnimalFemaleFibroblast Growth FactorsHippocampusLearningMaleMemoryMiceMice, KnockoutReceptor, Fibroblast Growth Factor, Type 2ConceptsFGF receptor 2Fibroblast growth factorDentate gyrusReceptor 2Embryonic knockoutWater maze probe trialGrowth factor receptor 2Reference memoryFactor receptor 2Spatial reference memoryNeural stem cellsFibroblast growth factor receptor 2Immature neuronsCortical neuronsHippocampal volumeInducible knockout miceParvalbumin interneuronsShort-term learningGranule cellsKnockout miceSeparate cellular componentsHippocampusLong-term reference memoryAdult spatial memoryGrowth factor
2006
Midline radial glia translocation and corpus callosum formation require FGF signaling
Smith KM, Ohkubo Y, Maragnoli ME, Rašin M, Schwartz ML, Šestan N, Vaccarino FM. Midline radial glia translocation and corpus callosum formation require FGF signaling. Nature Neuroscience 2006, 9: 787-797. PMID: 16715082, DOI: 10.1038/nn1705.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAstrocytesCell MovementCell ShapeCerebral CortexCorpus CallosumDown-RegulationFemaleFibroblast Growth Factor 8Fibroblast Growth FactorsGrowth ConesMaleMiceMice, KnockoutMice, TransgenicNeurogliaReceptor, Fibroblast Growth Factor, Type 1Receptor, Fibroblast Growth Factor, Type 2RNA InterferenceSignal TransductionConceptsRadial glial cellsGlial cellsSomal translocationRadial gliaCorpus callosum formationReceptor 1 geneCallosal dysgenesisCerebral cortexFibroblast growth factor receptor 1 (FGFR1) geneIndusium griseumDorsomedial cortexDorsolateral cortexKnockout miceCortexAstrogliaApical endfeetFGFR1 geneAstrocytesGliaAxon guidanceDorsal midlinePrecise targetingCellsUnexpected roleFGF
1999
Changes in cerebral cortex size are governed by fibroblast growth factor during embryogenesis
Vaccarino F, Schwartz M, Raballo R, Nilsen J, Rhee J, Zhou M, Doetschman T, Coffin J, Wyland J, Hung Y. Changes in cerebral cortex size are governed by fibroblast growth factor during embryogenesis. Nature Neuroscience 1999, 2: 246-253. PMID: 10195217, DOI: 10.1038/6350.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCerebral CortexEmbryo, MammalianEmbryonic and Fetal DevelopmentFibroblast Growth Factor 2Fibroblast Growth FactorsMiceMice, KnockoutMicroinjectionsRatsStem CellsConceptsPseudostratified ventricular epitheliumFibroblast growth factor-2Number of gliaAdult cerebral cortexEnd of neurogenesisCerebral cortex sizeFibroblast growth factorGrowth factor 2Cerebral cortexCerebral ventricleSingle microinjectionCortical neuronsBrdU studiesCortical progenitorsVentricular epitheliumCortex sizeGrowth factorRat embryosFGF2 geneEarly neurogenesisFGF receptorsFactor 2GliaNeurogenesisCell cycle length6 Fibroblast Growth Factor Signaling Regulates Growth and Morphogenesis at Multiple Steps during Brain Development11This work represents a collaboration between the laboratories of the first two authors.
Vaccarino F, Schwartz M, Raballo R, Rhee J, Lyn-Cook R. 6 Fibroblast Growth Factor Signaling Regulates Growth and Morphogenesis at Multiple Steps during Brain Development11This work represents a collaboration between the laboratories of the first two authors. Current Topics In Developmental Biology 1999, 46: 179-200. PMID: 10417880, DOI: 10.1016/s0070-2153(08)60329-4.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsCentral nervous system regionsNervous system regionsCentral nervous systemRole of FGF2Growth factor familyCerebral cortexFibroblast growth factor (FGF) familyCortical developmentNervous systemFibroblast growth factor (FGF) signalingGrowth factor signalingSystem regionsFactor signalingMolecular mechanismsCoordinated activationDistinct patternsTarget genesFGF2FGFFactor familyCortex