A1 adenosine receptor activation induces ventriculomegaly and white matter loss
Turner CP, Yan H, Schwartz M, Othman T, Rivkees SA. A1 adenosine receptor activation induces ventriculomegaly and white matter loss. Neuroreport 2002, 13: 1199-1204. PMID: 12151769, DOI: 10.1097/00001756-200207020-00026.Peer-Reviewed Original ResearchMeSH KeywordsAdenosineAnimalsAnimals, NewbornBody WeightCell CountCerebral CortexCerebral VentriclesDrug CombinationsDrug InteractionsGTP-Binding ProteinsGuanosine 5'-O-(3-Thiotriphosphate)HippocampusMicroscopy, ElectronMyelin Basic ProteinNerve DegenerationNerve Fibers, MyelinatedNeurogliaNeuronsPresynaptic TerminalsPurinergic P1 Receptor AgonistsPurinergic P1 Receptor AntagonistsRatsRats, Sprague-DawleyReceptors, Purinergic P1TelencephalonTheophyllineConceptsWhite matter lossAdenosine receptor activationActivation of A1ARPostnatal day 3White matter volumeReceptor-G protein couplingMyelin basic proteinNeuronal lossAgonist treatmentNeonatal ratsN6-cyclopentyladenosineA1AR activationMatter volumeDay 3Adenosine receptorsReceptor activationBrain formationPD 4A1ARReduced expressionProtein couplingQuantitative electron microscopyVentriculomegalyBasic proteinBrain