2014
A Tarantula-Venom Peptide Antagonizes the TRPA1 Nociceptor Ion Channel by Binding to the S1–S4 Gating Domain
Gui J, Liu B, Cao G, Lipchik AM, Perez M, Dekan Z, Mobli M, Daly NL, Alewood PF, Parker LL, King GF, Zhou Y, Jordt SE, Nitabach MN. A Tarantula-Venom Peptide Antagonizes the TRPA1 Nociceptor Ion Channel by Binding to the S1–S4 Gating Domain. Current Biology 2014, 24: 473-483. PMID: 24530065, PMCID: PMC3949122, DOI: 10.1016/j.cub.2014.01.013.Peer-Reviewed Original ResearchMeSH KeywordsAmino Acid SequenceAnimalsBinding SitesDrug Evaluation, PreclinicalFemaleGene LibraryHumansMolecular Sequence DataNAV1.2 Voltage-Gated Sodium ChannelOocytesPeptidesProtein Structure, TertiarySpider VenomsTransient Receptor Potential ChannelsVoltage-Gated Sodium Channel BlockersXenopus ProteinsConceptsTransient receptor potential ankyrin 1Ion channel modifiersProTxIon channel transient receptor potential ankyrin 1Channel modifiersPeptide toxinsSpecific peptidesIon channelsVoltage-gated sodium channelsContext of painS1-S4Spider venomPotential clinical applicationsTRPA1 antagonistTRPA1 functionAnkyrin 1PeptidesModifiersPeptide antagonistAntagonistSodium channelsPharmacological reagentsReagentsClinical applicationNav1.2
2013
Membrane-Tethered Ligands: Tools for Cell-Autonomous Pharmacological Manipulation of Biological Circuits
Choi C, Nitabach MN. Membrane-Tethered Ligands: Tools for Cell-Autonomous Pharmacological Manipulation of Biological Circuits. Physiology 2013, 28: 164-171. PMID: 23636262, PMCID: PMC4073904, DOI: 10.1152/physiol.00056.2012.Peer-Reviewed Original ResearchConceptsMembrane-tethered ligandsCellular circuitsCell surface receptorsCognate cell surface receptorsCell-autonomous mannerG protein-coupled receptorsCell-specific promoterIon channel subtypesIntercellular communication pathwaysRecombinant transgeneBiological processesStructural modulesBiological circuitsBiological significanceIon channelsSpecific phenotypesSurface receptorsCommunication pathwaysPhysiological circuitsSpecific manipulationChannel subtypesReceptorsSuch manipulationsPharmacological manipulationPromoter