Mutations in Drosophila sec15 Reveal a Function in Neuronal Targeting for a Subset of Exocyst Components
Mehta SQ, Hiesinger PR, Beronja S, Zhai RG, Schulze KL, Verstreken P, Cao Y, Zhou Y, Tepass U, Crair MC, Bellen HJ. Mutations in Drosophila sec15 Reveal a Function in Neuronal Targeting for a Subset of Exocyst Components. Neuron 2005, 46: 219-232. PMID: 15848801, DOI: 10.1016/j.neuron.2005.02.029.Peer-Reviewed Original ResearchConceptsExocyst componentsComplex of proteinsCell polaritySec15Specific cell adhesionSpecific proteinsMutant neuronsSubcellular distributionCell adhesionCell lethalityExocystNeuronal targetingSec5Neurite outgrowthSynaptic specificityCell viabilityProteinSeparable functionsSec6Sec8SubcomplexMislocalizationYeastGenesComponents persist