2010
The Immune Protein CD3ζ Is Required for Normal Development of Neural Circuits in the Retina
Xu HP, Chen H, Ding Q, Xie ZH, Chen L, Diao L, Wang P, Gan L, Crair MC, Tian N. The Immune Protein CD3ζ Is Required for Normal Development of Neural Circuits in the Retina. Neuron 2010, 65: 503-515. PMID: 20188655, PMCID: PMC3037728, DOI: 10.1016/j.neuron.2010.01.035.Peer-Reviewed Original ResearchConceptsEye-specific segregationCentral nervous systemRetinal ganglion cellsDendritic motilitySynaptic activityActivity-dependent synapse formationPossible retinal originRGC axon projectionImmune proteinsImmune-deficient miceDendritic densityGanglion cellsClass I major histocompatibility complex genesRetinal originNervous systemSynapse formationAxon projectionsMHCI receptorNeural circuitsSynaptic wiringSelective defectMajor histocompatibility complex (MHC) genesMiceRetinaNormal development
2008
State-Dependent Bidirectional Modification of Somatic Inhibition in Neocortical Pyramidal Cells
Kurotani T, Yamada K, Yoshimura Y, Crair MC, Komatsu Y. State-Dependent Bidirectional Modification of Somatic Inhibition in Neocortical Pyramidal Cells. Neuron 2008, 57: 905-916. PMID: 18367091, PMCID: PMC2880402, DOI: 10.1016/j.neuron.2008.01.030.Peer-Reviewed Original ResearchMeSH Keywords2-Amino-5-phosphonovalerateAction PotentialsAnimalsAnimals, NewbornBicucullineDendritesDose-Response Relationship, DrugDose-Response Relationship, RadiationElectric StimulationExcitatory Amino Acid AntagonistsGABA AntagonistsGamma-Aminobutyric AcidInhibitory Postsynaptic PotentialsNeural InhibitionPatch-Clamp TechniquesPyramidal CellsQuinoxalinesRatsRats, Sprague-DawleySpider VenomsVisual CortexConceptsL-type Ca2Slow-wave sleepSomatic inhibitionPyramidal neuronsLayer 5 pyramidal neuronsBidirectional modificationSlow membrane oscillationsRat visual cortexCortical pyramidal neuronsR-type Ca2Neocortical pyramidal cellsBehavioral statesNeuron responsivenessPyramidal cellsDepolarized phaseRepetitive firingVisual cortexReceptor exocytosisChannel activationInhibitionPotentiationNeuronsSleepMembrane oscillationsDepression
1998
Morphology of Single Geniculocortical Afferents and Functional Recovery of the Visual Cortex after Reverse Monocular Deprivation in the Kitten
Antonini A, Gillespie DC, Crair MC, Stryker MP. Morphology of Single Geniculocortical Afferents and Functional Recovery of the Visual Cortex after Reverse Monocular Deprivation in the Kitten. Journal Of Neuroscience 1998, 18: 9896-9909. PMID: 9822746, PMCID: PMC2452997, DOI: 10.1523/jneurosci.18-23-09896.1998.Peer-Reviewed Original ResearchConceptsLateral geniculate nucleusMonocular deprivationFunctional recoveryGeniculocortical afferentsArea 17Visual cortical responsesInitial deprivationSimilar proportional changesTotal arbor lengthPossible anatomical basisLayer IVArbor lengthGeniculate nucleusCortical responsesAfferent arborsSecond deprivationLamina ANormal animalsVisual cortexPlastic changesAnatomical basisInitial weeksArborsEyesAfferents