2019
Visual Cortex Gains Independence from Peripheral Drive before Eye Opening
Gribizis A, Ge X, Daigle TL, Ackman JB, Zeng H, Lee D, Crair MC. Visual Cortex Gains Independence from Peripheral Drive before Eye Opening. Neuron 2019, 104: 711-723.e3. PMID: 31561919, PMCID: PMC6872942, DOI: 10.1016/j.neuron.2019.08.015.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsFemaleMaleMice, Inbred C57BLNeurogenesisSuperior ColliculiVisual CortexVisual PathwaysConceptsSuperior colliculusEarly functional developmentSpontaneous neuronal activitySecond postnatal weekPrimary visual cortexPeripheral driveCortex maturesRetinal activityPostnatal weekNeuronal activityDirect projectionsVisual cortexMammalian brainSensory peripheryVisual-spatial perceptionEye openingFunctional developmentPeripheral activityColliculusWeeksDistinct pathwaysPathwayRelative functionV1ThalamusSynapse-Selective Control of Cortical Maturation and Plasticity by Parvalbumin-Autonomous Action of SynCAM 1
Ribic A, Crair MC, Biederer T. Synapse-Selective Control of Cortical Maturation and Plasticity by Parvalbumin-Autonomous Action of SynCAM 1. Cell Reports 2019, 26: 381-393.e6. PMID: 30625321, PMCID: PMC6345548, DOI: 10.1016/j.celrep.2018.12.069.Peer-Reviewed Original ResearchConceptsCortical plasticityCell adhesion molecule-1Critical periodJuvenile-like plasticityAdhesion molecule-1Primary visual cortexVisual critical periodThalamocortical inputsCortical maturationCircuit maturationV1 plasticityParvalbumin interneuronsFeedforward inhibitionSynaptic cell adhesion molecule 1Cell-autonomous mechanismsBrief lossCortical responsesSynaptic lociMolecule-1Visual cortexSynaptic factorsInterneuronsSpecific knockdownAdulthoodEyes
2018
Restoration of vision after de novo genesis of rod photoreceptors in mammalian retinas
Yao K, Qiu S, Wang YV, Park SJH, Mohns EJ, Mehta B, Liu X, Chang B, Zenisek D, Crair MC, Demb JB, Chen B. Restoration of vision after de novo genesis of rod photoreceptors in mammalian retinas. Nature 2018, 560: 484-488. PMID: 30111842, PMCID: PMC6107416, DOI: 10.1038/s41586-018-0425-3.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBeta CateninBlindnessCell CycleCell ProliferationCellular ReprogrammingDisease Models, AnimalFemaleGTP-Binding Protein alpha SubunitsHeterotrimeric GTP-Binding ProteinsMaleMiceNeurogenesisNeurogliaRegenerative MedicineRetinal Rod Photoreceptor CellsStem CellsTranscription FactorsTransducinVisual CortexVisual PathwaysConceptsMüller gliaGene transferMG proliferationRod photoreceptorsMammalian retinaCell fate specificationPopulations of stemSubsequent gene transferFate specificationRetinal stem cellsTranscription factorsRetinal neuronsCell cycleDouble mutant miceRegenerative machineryDe novo genesisΒ-cateninStem cellsProgenitor cellsRestoration of visionPrimary visual cortexMutant miceAbsence of injuryPhotoreceptorsRetinal injury
2013
Role of emergent neural activity in visual map development
Ackman JB, Crair MC. Role of emergent neural activity in visual map development. Current Opinion In Neurobiology 2013, 24: 166-175. PMID: 24492092, PMCID: PMC3957181, DOI: 10.1016/j.conb.2013.11.011.Peer-Reviewed Original ResearchConceptsRetinal wavesNeural activitySpontaneous activityNormal visual functionOnset of visionVisual functionGestational periodCalcium influxFunctional visionLong gestational periodNervous systemVisual circuitsNeurotransmitter releaseNerve cellsAssociative circuitsCircuit connectivitySensory-motor systemEye openingFunctional developmentVisuomotor learningSpecific spatiotemporal patternsSpontaneous patternsExcitable cellsOnsetFuture studies
2009
Consequences of axon guidance defects on the development of retinotopic receptive fields in the mouse colliculus
Chandrasekaran AR, Furuta Y, Crair MC. Consequences of axon guidance defects on the development of retinotopic receptive fields in the mouse colliculus. The Journal Of Physiology 2009, 587: 953-963. PMID: 19153163, PMCID: PMC2673768, DOI: 10.1113/jphysiol.2008.160952.Peer-Reviewed Original ResearchConceptsSuperior colliculusMutant miceBone morphogenetic protein receptorRetinal ganglion cell axonsGuidance moleculesSpontaneous retinal wavesGanglion cell axonsSuperficial superior colliculusReceptive field propertiesRetinotopic receptive fieldsActivity-dependent factorsMore RGCsRetinocollicular projectionRetinal wavesEctopic projectionsVentral retinaCell axonsRetinotopic map formationAnatomical defectsAction potentialsActivity-dependent learning ruleSpontaneous wavesRetinaRGCsMice