2008
Bone Morphogenetic Proteins, Eye Patterning, and Retinocollicular Map Formation in the Mouse
Plas DT, Dhande OS, Lopez JE, Murali D, Thaller C, Henkemeyer M, Furuta Y, Overbeek P, Crair MC. Bone Morphogenetic Proteins, Eye Patterning, and Retinocollicular Map Formation in the Mouse. Journal Of Neuroscience 2008, 28: 7057-7067. PMID: 18614674, PMCID: PMC2667968, DOI: 10.1523/jneurosci.3598-06.2008.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAnimals, NewbornBone Morphogenetic Protein 2Bone Morphogenetic Protein Receptors, Type IBone Morphogenetic ProteinsCarrier ProteinsEyeHumansIn Vitro TechniquesMiceMice, TransgenicMutationRetinaSuperior ColliculiTransforming Growth Factor betaVisual PathwaysXenopusConceptsLateral geniculate nucleusSuperior colliculusOptic tractRetinotopic map formationRetinal ganglion cell axonsBone morphogenetic proteinCentral brain targetsRetinocollicular map formationGanglion cell axonsMap formationWild-type miceStrains of miceAxon behaviorEarly eye formationAxon orderRetinal cell fateOptic chiasmRGC axonsBrain targetsGeniculate nucleusCell axonsPotential downstream effectorsAxon sortingMorphogenetic proteinsMice
2005
Distinct developmental programs require different levels of Bmp signaling during mouse retinal development
Murali D, Yoshikawa S, Corrigan RR, Plas DJ, Crair MC, Oliver G, Lyons KM, Mishina Y, Furuta Y. Distinct developmental programs require different levels of Bmp signaling during mouse retinal development. Development 2005, 132: 913-923. PMID: 15673568, DOI: 10.1242/dev.01673.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBody PatterningBone Morphogenetic Protein Receptors, Type IBone Morphogenetic ProteinsCell ProliferationChromosome MappingFibroblast Growth FactorsGene Expression Regulation, DevelopmentalImmunohistochemistryIn Situ HybridizationMiceMice, TransgenicModels, BiologicalModels, GeneticMutationNeuronsOptic NerveProtein Serine-Threonine KinasesReceptors, Growth FactorRetinaSignal TransductionTransgenesConceptsDistinct developmental programsDevelopmental programRetinal developmentBMP receptor activityReceptor geneCell-autonomous requirementCre-loxP strategySevere eye defectsDirect genetic evidenceEmbryonic tissue interactionsMouse retinal developmentEye abnormalitiesMutant backgroundDorsoventral patterningMouse retinaReceptor activityDouble mutantReceptor functionEmbryonic retinaBMP familyRedundant rolesRetinal neurogenesisFunctional copyEmbryonic developmentGenetic evidence