2021
Retinal waves prime visual motion detection by simulating future optic flow
Ge X, Zhang K, Gribizis A, Hamodi AS, Sabino AM, Crair MC. Retinal waves prime visual motion detection by simulating future optic flow. Science 2021, 373 PMID: 34437090, PMCID: PMC8841103, DOI: 10.1126/science.abd0830.Peer-Reviewed Original ResearchConceptsEye-specific segregationSpontaneous retinal wavesVisual response propertiesSpontaneous retinal activityDirection-selective responsesSuperior colliculus neuronsOptic flow patternsRetinal wavesRetinal activityColliculus neuronsRetinal circuitsSpontaneous activityChronic disruptionVisual motion detectionEye openingTransient windowResponse propertiesOptic flowSensory experienceNeurons
2020
Retinal and Callosal Activity-Dependent Chandelier Cell Elimination Shapes Binocularity in Primary Visual Cortex
Wang BS, Bernardez Sarria MS, An X, He M, Alam NM, Prusky GT, Crair MC, Huang ZJ. Retinal and Callosal Activity-Dependent Chandelier Cell Elimination Shapes Binocularity in Primary Visual Cortex. Neuron 2020, 109: 502-515.e7. PMID: 33290732, PMCID: PMC7943176, DOI: 10.1016/j.neuron.2020.11.004.Peer-Reviewed Original ResearchConceptsPrimary visual cortexVisual cortexTranscallosal pathwayVisual fieldDeficient binocular visionGABAergic chandelier cellsBinocular circuitsBinocular visionChandelier cellsRetinal activityTranscallosal projectionsGeniculocortical inputCallosal activityCenter visual fieldBinocular regionCortexMassive apoptosisDevelopmental assemblyCritical periodV1IpsiBlockadePathwayBinocularityMice
2019
Visual Cortex Gains Independence from Peripheral Drive before Eye Opening
Gribizis A, Ge X, Daigle TL, Ackman JB, Zeng H, Lee D, Crair MC. Visual Cortex Gains Independence from Peripheral Drive before Eye Opening. Neuron 2019, 104: 711-723.e3. PMID: 31561919, PMCID: PMC6872942, DOI: 10.1016/j.neuron.2019.08.015.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsFemaleMaleMice, Inbred C57BLNeurogenesisSuperior ColliculiVisual CortexVisual PathwaysConceptsSuperior colliculusEarly functional developmentSpontaneous neuronal activitySecond postnatal weekPrimary visual cortexPeripheral driveCortex maturesRetinal activityPostnatal weekNeuronal activityDirect projectionsVisual cortexMammalian brainSensory peripheryVisual-spatial perceptionEye openingFunctional developmentPeripheral activityColliculusWeeksDistinct pathwaysPathwayRelative functionV1Thalamus
2018
Restoration of vision after de novo genesis of rod photoreceptors in mammalian retinas
Yao K, Qiu S, Wang YV, Park SJH, Mohns EJ, Mehta B, Liu X, Chang B, Zenisek D, Crair MC, Demb JB, Chen B. Restoration of vision after de novo genesis of rod photoreceptors in mammalian retinas. Nature 2018, 560: 484-488. PMID: 30111842, PMCID: PMC6107416, DOI: 10.1038/s41586-018-0425-3.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBeta CateninBlindnessCell CycleCell ProliferationCellular ReprogrammingDisease Models, AnimalFemaleGTP-Binding Protein alpha SubunitsHeterotrimeric GTP-Binding ProteinsMaleMiceNeurogenesisNeurogliaRegenerative MedicineRetinal Rod Photoreceptor CellsStem CellsTranscription FactorsTransducinVisual CortexVisual PathwaysConceptsMüller gliaGene transferMG proliferationRod photoreceptorsMammalian retinaCell fate specificationPopulations of stemSubsequent gene transferFate specificationRetinal stem cellsTranscription factorsRetinal neuronsCell cycleDouble mutant miceRegenerative machineryDe novo genesisΒ-cateninStem cellsProgenitor cellsRestoration of visionPrimary visual cortexMutant miceAbsence of injuryPhotoreceptorsRetinal injury
2017
Architecture, Function, and Assembly of the Mouse Visual System
Seabrook TA, Burbridge TJ, Crair MC, Huberman AD. Architecture, Function, and Assembly of the Mouse Visual System. Annual Review Of Neuroscience 2017, 40: 499-538. PMID: 28772103, DOI: 10.1146/annurev-neuro-071714-033842.Peer-Reviewed Original ResearchConceptsSpecific cell typesMammalian central nervous systemGenetic perturbationsModel speciesCell typesCausal testingSpeciesVivo labelingBroad scaleVisual system structuresManipulation of neuronsSensory systemsCentral nervous systemVisual circuitryPowerful toolNervous systemLarge cadreHumansMouse visual systemAdditional experimentationPathwayFunctionConvenient sizeAssemblyVisual systemReciprocal Connections Between Cortex and Thalamus Contribute to Retinal Axon Targeting to Dorsal Lateral Geniculate Nucleus
Diao Y, Cui L, Chen Y, Burbridge TJ, Han W, Wirth B, Sestan N, Crair MC, Zhang J. Reciprocal Connections Between Cortex and Thalamus Contribute to Retinal Axon Targeting to Dorsal Lateral Geniculate Nucleus. Cerebral Cortex 2017, 28: 1168-1182. PMID: 28334242, PMCID: PMC6059179, DOI: 10.1093/cercor/bhx028.Peer-Reviewed Original ResearchMeSH KeywordsAction PotentialsAnimalsAnimals, NewbornAxonsCalciumCholera ToxinDNA-Binding ProteinsEmbryo, MammalianExcitatory Amino Acid AgonistsFeeding BehaviorGene Expression Regulation, DevelopmentalGeniculate BodiesGreen Fluorescent ProteinsHomeodomain ProteinsMiceMice, TransgenicNerve Tissue ProteinsRetinaSerine-Arginine Splicing FactorsSuperior ColliculiTranscription FactorsVisual CortexVisual PathwaysConceptsDorsal lateral geniculate nucleusLateral geniculate nucleusVentral lateral geniculate nucleusGeniculate nucleusRetinal projectionsReciprocal connectionsSuperior colliculusConditional knockoutVivo electrophysiology experimentsAbnormal retinal projectionsPrimary visual cortexDLGN neuronsCorticothalamic inputsControl miceThalamocortical tractV1 lesionsThalamus contributeRetinal innervationThalamocortical projectionsCKO miceMouse modelRetinal inputVisual cortexVisual circuitsAxon targetingActivity-dependent development of visual receptive fields
Thompson A, Gribizis A, Chen C, Crair MC. Activity-dependent development of visual receptive fields. Current Opinion In Neurobiology 2017, 42: 136-143. PMID: 28088066, PMCID: PMC5375035, DOI: 10.1016/j.conb.2016.12.007.Peer-Reviewed Original Research
2016
Reconnecting Eye to Brain
Crair MC, Mason CA. Reconnecting Eye to Brain. Journal Of Neuroscience 2016, 36: 10707-10722. PMID: 27798125, PMCID: PMC5083002, DOI: 10.1523/jneurosci.1711-16.2016.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAxonsBrainHumansOcular Physiological PhenomenaOptic NerveRetinal Ganglion CellsVisual PathwaysConceptsAudacious Goals InitiativeNational Eye InstituteRetinal ganglion cellsSystem regenerationEye InstituteGanglion cellsVisual functionTraumatic injuryVisual system functionNeural regenerationTarget engagementDisease-induced degenerationRegenerative capacityVisual systemAxon guidanceSystem functionSignificant barriersCurrent understandingSatellite meetingInjuryAxonsDegenerationNeuronsBrainRetinal Wave Patterns Are Governed by Mutual Excitation among Starburst Amacrine Cells and Drive the Refinement and Maintenance of Visual Circuits
Xu HP, Burbridge TJ, Ye M, Chen M, Ge X, Zhou ZJ, Crair MC. Retinal Wave Patterns Are Governed by Mutual Excitation among Starburst Amacrine Cells and Drive the Refinement and Maintenance of Visual Circuits. Journal Of Neuroscience 2016, 36: 3871-3886. PMID: 27030771, PMCID: PMC4812142, DOI: 10.1523/jneurosci.3549-15.2016.Peer-Reviewed Original ResearchMeSH KeywordsAction PotentialsAge FactorsAmacrine CellsAnimalsAnimals, NewbornCalciumCholera ToxinCholine O-AcetyltransferaseCholinergic AgentsGene Expression Regulation, DevelopmentalGreen Fluorescent ProteinsIn Vitro TechniquesMiceMice, TransgenicPatch-Clamp TechniquesReceptors, NicotinicRetinaRetinal Ganglion CellsVesicular Glutamate Transport Protein 1Visual PathwaysConceptsEye-specific segregationVisual circuit developmentStarburst amacrine cellsStage III retinal wavesRetinal ganglion cellsRetinal wavesAmacrine cellsGlutamatergic wavesGanglion cellsSpontaneous activityVisual circuitsStage IICircuit developmentHigher-order visual areasNicotinic acetylcholine receptorsRetinal cell typesMammalian visual systemAcetylcholine receptorsΒ2-nAChRsVisual areasPatterned activityPatterning of activityΒ2 subunitCell typesCells
2015
Spatial pattern of spontaneous retinal waves instructs retinotopic map refinement more than activity frequency
Xu HP, Burbridge TJ, Chen MG, Ge X, Zhang Y, Zhou ZJ, Crair MC. Spatial pattern of spontaneous retinal waves instructs retinotopic map refinement more than activity frequency. Developmental Neurobiology 2015, 75: 621-640. PMID: 25787992, PMCID: PMC4697738, DOI: 10.1002/dneu.22288.Peer-Reviewed Original ResearchConceptsSpontaneous retinal activityEye-specific segregationRetinal activityRetinal ganglion cell projectionsEye-specific projectionsGanglion cell projectionsPrecise neural connectionsRetinotopic map refinementSpontaneous retinal wavesNicotinic acetylcholine receptorsInstructive roleEye of originRetinal wavesRetinotopic refinementSpontaneous activityRetinotopic mapAcetylcholine receptorsDevelopment of retinotopyBrain wiringPermissive roleMutant miceNeural connectionsOverall activity levelsSpontaneous wavesMice
2014
Visual Circuit Development Requires Patterned Activity Mediated by Retinal Acetylcholine Receptors
Burbridge TJ, Xu HP, Ackman JB, Ge X, Zhang Y, Ye MJ, Zhou ZJ, Xu J, Contractor A, Crair MC. Visual Circuit Development Requires Patterned Activity Mediated by Retinal Acetylcholine Receptors. Neuron 2014, 84: 1049-1064. PMID: 25466916, PMCID: PMC4258148, DOI: 10.1016/j.neuron.2014.10.051.Peer-Reviewed Original ResearchMeSH KeywordsAction PotentialsAge FactorsAnalysis of VarianceAnimalsAnimals, NewbornCalciumCyclic AMPCyclic GMPCyclooxygenase InhibitorsEye ProteinsFunctional LateralityHomeodomain ProteinsIn Vitro TechniquesMeclofenamic AcidMiceMice, TransgenicPaired Box Transcription FactorsPAX6 Transcription FactorReceptors, NicotinicRepressor ProteinsRetinaRetinal Ganglion CellsRNA, MessengerVisual PathwaysConceptsRetinal wavesCircuit refinementNervous systemNeural circuitsVisual circuit developmentSpontaneous retinal activityRetinal activityRetinorecipient regionsSpontaneous activityAcetylcholine receptorsPharmacological manipulationVisual circuitsSynaptic connectionsVertebrate nervous systemNeural activityOnset of sensationAltered patternCircuit developmentSensory systemsCausal linkEarly developmentActivityBrainReceptors
2013
Role of emergent neural activity in visual map development
Ackman JB, Crair MC. Role of emergent neural activity in visual map development. Current Opinion In Neurobiology 2013, 24: 166-175. PMID: 24492092, PMCID: PMC3957181, DOI: 10.1016/j.conb.2013.11.011.Peer-Reviewed Original ResearchConceptsRetinal wavesNeural activitySpontaneous activityNormal visual functionOnset of visionVisual functionGestational periodCalcium influxFunctional visionLong gestational periodNervous systemVisual circuitsNeurotransmitter releaseNerve cellsAssociative circuitsCircuit connectivitySensory-motor systemEye openingFunctional developmentVisuomotor learningSpecific spatiotemporal patternsSpontaneous patternsExcitable cellsOnsetFuture studies
2012
Synapse maturation is enhanced in the binocular region of the retinocollicular map prior to eye opening
Furman M, Crair MC. Synapse maturation is enhanced in the binocular region of the retinocollicular map prior to eye opening. Journal Of Neurophysiology 2012, 107: 3200-3216. PMID: 22402661, PMCID: PMC3774562, DOI: 10.1152/jn.00943.2011.Peer-Reviewed Original ResearchConceptsSuperior colliculusLateral superior colliculusMedial superior colliculusEye openingP6-7Synaptic strengthBinocular interactionEye-specific segregationPatch-clamp recordingsRetinocollicular synapsesIpsilateral eyeNeonatal miceSlice preparationSynaptic basisMonocular enucleationDendritic arborsSynapse maturationTarget neuronsRetinal axonsDendritic branchingRetinocollicular mapSynaptic connectivityPostsynaptic partnersBinocular competitionSynapse developmentRole of adenylate cyclase 1 in retinofugal map development
Dhande OS, Bhatt S, Anishchenko A, Elstrott J, Iwasato T, Swindell EC, Xu H, Jamrich M, Itohara S, Feller MB, Crair MC. Role of adenylate cyclase 1 in retinofugal map development. The Journal Of Comparative Neurology 2012, 520: 1562-1583. PMID: 22102330, PMCID: PMC3563095, DOI: 10.1002/cne.23000.Peer-Reviewed Original ResearchConceptsLateral geniculate nucleusDorsal lateral geniculate nucleusAdenylate cyclase 1Superior colliculusRetinal wavesRetinal ganglion cell projectionsEye-specific segregationGanglion cell projectionsSpontaneous retinal wavesSecond postnatal weekActivity-dependent processesCyclase 1Production of cAMPRGC axonsGeniculate nucleusPostnatal weekMammalian visual systemDevelopment of retinotopySomatotopic mapMutant miceSensory peripheryMiceConditional deletionTermination zonesDependent manner
2011
Visual map development depends on the temporal pattern of binocular activity in mice
Zhang J, Ackman JB, Xu HP, Crair MC. Visual map development depends on the temporal pattern of binocular activity in mice. Nature Neuroscience 2011, 15: 298-307. PMID: 22179110, PMCID: PMC3267873, DOI: 10.1038/nn.3007.Peer-Reviewed Original ResearchMeSH KeywordsAction PotentialsAnimalsAnimals, NewbornBrain MappingCalciumChannelrhodopsinsCritical Period, PsychologicalFunctional LateralityIn Vitro TechniquesLightLuminescent ProteinsMiceMice, Inbred C57BLMice, TransgenicNeuronal PlasticityPatch-Clamp TechniquesReceptors, NicotinicRetinaRetinal Ganglion CellsSuperior ColliculiTime FactorsVision, BinocularVisual PathwaysConceptsDorsal lateral geniculate nucleusEye-specific segregationSpontaneous retinal wavesLateral geniculate nucleusPrimary visual cortexMouse visual systemBinocular activityRetinal wavesGeniculate nucleusCircuit refinementSuperior colliculusSpecific temporal featuresVisual cortexBursts of activityDefinitive evidenceVisual systemColliculusBinocularityCortexMiceActivityAn Instructive Role for Patterned Spontaneous Retinal Activity in Mouse Visual Map Development
Xu HP, Furman M, Mineur YS, Chen H, King SL, Zenisek D, Zhou ZJ, Butts DA, Tian N, Picciotto MR, Crair MC. An Instructive Role for Patterned Spontaneous Retinal Activity in Mouse Visual Map Development. Neuron 2011, 70: 1115-1127. PMID: 21689598, PMCID: PMC3119851, DOI: 10.1016/j.neuron.2011.04.028.Peer-Reviewed Original ResearchConceptsSpontaneous retinal activityRetinal activityRetinal ganglion cell projectionsEye-specific segregationGanglion cell projectionsSpontaneous retinal wavesActivity-dependent refinementRetinal ganglion cellsMouse visual systemComplex neural circuitsEye of originRetinal wavesGanglion cellsRetinotopic refinementNeuronal activitySpontaneous activityMammalian visual systemAcetylcholine receptorsNeuronal connectivityMammalian brainNeural circuitsOverall activity levelsActivity levelsBrainVisual systemDevelopment of Single Retinofugal Axon Arbors in Normal and β2 Knock-Out Mice
Dhande OS, Hua EW, Guh E, Yeh J, Bhatt S, Zhang Y, Ruthazer ES, Feller MB, Crair MC. Development of Single Retinofugal Axon Arbors in Normal and β2 Knock-Out Mice. Journal Of Neuroscience 2011, 31: 3384-3399. PMID: 21368050, PMCID: PMC3060716, DOI: 10.1523/jneurosci.4899-10.2011.Peer-Reviewed Original ResearchConceptsDorsal lateral geniculate nucleusRetinal ganglion cellsSuperior colliculusAxon arborsRetinotopic refinementEye-specific segregationReceptor mutant miceLateral geniculate nucleusActivity-dependent mechanismsNormal developmentWT miceRGC axonsRetinal wavesGanglion cellsGeniculate nucleusMutant miceRole of activityMiceSpecific cuesArborsSparse branchesSame ageLabeling techniqueMaturationDevelopmental period
2010
The Immune Protein CD3ζ Is Required for Normal Development of Neural Circuits in the Retina
Xu HP, Chen H, Ding Q, Xie ZH, Chen L, Diao L, Wang P, Gan L, Crair MC, Tian N. The Immune Protein CD3ζ Is Required for Normal Development of Neural Circuits in the Retina. Neuron 2010, 65: 503-515. PMID: 20188655, PMCID: PMC3037728, DOI: 10.1016/j.neuron.2010.01.035.Peer-Reviewed Original ResearchConceptsEye-specific segregationCentral nervous systemRetinal ganglion cellsDendritic motilitySynaptic activityActivity-dependent synapse formationPossible retinal originRGC axon projectionImmune proteinsImmune-deficient miceDendritic densityGanglion cellsClass I major histocompatibility complex genesRetinal originNervous systemSynapse formationAxon projectionsMHCI receptorNeural circuitsSynaptic wiringSelective defectMajor histocompatibility complex (MHC) genesMiceRetinaNormal development
2009
Consequences of axon guidance defects on the development of retinotopic receptive fields in the mouse colliculus
Chandrasekaran AR, Furuta Y, Crair MC. Consequences of axon guidance defects on the development of retinotopic receptive fields in the mouse colliculus. The Journal Of Physiology 2009, 587: 953-963. PMID: 19153163, PMCID: PMC2673768, DOI: 10.1113/jphysiol.2008.160952.Peer-Reviewed Original ResearchConceptsSuperior colliculusMutant miceBone morphogenetic protein receptorRetinal ganglion cell axonsGuidance moleculesSpontaneous retinal wavesGanglion cell axonsSuperficial superior colliculusReceptive field propertiesRetinotopic receptive fieldsActivity-dependent factorsMore RGCsRetinocollicular projectionRetinal wavesEctopic projectionsVentral retinaCell axonsRetinotopic map formationAnatomical defectsAction potentialsActivity-dependent learning ruleSpontaneous wavesRetinaRGCsMice
2008
Bone Morphogenetic Proteins, Eye Patterning, and Retinocollicular Map Formation in the Mouse
Plas DT, Dhande OS, Lopez JE, Murali D, Thaller C, Henkemeyer M, Furuta Y, Overbeek P, Crair MC. Bone Morphogenetic Proteins, Eye Patterning, and Retinocollicular Map Formation in the Mouse. Journal Of Neuroscience 2008, 28: 7057-7067. PMID: 18614674, PMCID: PMC2667968, DOI: 10.1523/jneurosci.3598-06.2008.Peer-Reviewed Original ResearchConceptsLateral geniculate nucleusSuperior colliculusOptic tractRetinotopic map formationRetinal ganglion cell axonsBone morphogenetic proteinCentral brain targetsRetinocollicular map formationGanglion cell axonsMap formationWild-type miceStrains of miceAxon behaviorEarly eye formationAxon orderRetinal cell fateOptic chiasmRGC axonsBrain targetsGeniculate nucleusCell axonsPotential downstream effectorsAxon sortingMorphogenetic proteinsMice