Cortical Adenylyl Cyclase 1 Is Required for Thalamocortical Synapse Maturation and Aspects of Layer IV Barrel Development
Iwasato T, Inan M, Kanki H, Erzurumlu RS, Itohara S, Crair MC. Cortical Adenylyl Cyclase 1 Is Required for Thalamocortical Synapse Maturation and Aspects of Layer IV Barrel Development. Journal Of Neuroscience 2008, 28: 5931-5943. PMID: 18524897, PMCID: PMC2733830, DOI: 10.1523/jneurosci.0815-08.2008.Peer-Reviewed Original ResearchConceptsTC synapsesLayer IV barrel neuronsCritical period plasticityPrimary somatosensory cortexFormation of barrelsAdenylyl cyclase 1Knock-out (KO) miceType 1 adenylyl cyclaseDendritic asymmetryBarrel neuronsThalamocortical synapsesActivity-dependent mannerTrigeminal pathwayFormation of cAMPSomatosensory cortexBarrel cortexBarrel developmentSynapse maturationPresynaptic maturationBarrel hollowsTC axonsSubcortical regionsFunctional maturationMutant miceBRL mice