2015
Spatial pattern of spontaneous retinal waves instructs retinotopic map refinement more than activity frequency
Xu HP, Burbridge TJ, Chen MG, Ge X, Zhang Y, Zhou ZJ, Crair MC. Spatial pattern of spontaneous retinal waves instructs retinotopic map refinement more than activity frequency. Developmental Neurobiology 2015, 75: 621-640. PMID: 25787992, PMCID: PMC4697738, DOI: 10.1002/dneu.22288.Peer-Reviewed Original ResearchConceptsSpontaneous retinal activityEye-specific segregationRetinal activityRetinal ganglion cell projectionsEye-specific projectionsGanglion cell projectionsPrecise neural connectionsRetinotopic map refinementSpontaneous retinal wavesNicotinic acetylcholine receptorsInstructive roleEye of originRetinal wavesRetinotopic refinementSpontaneous activityRetinotopic mapAcetylcholine receptorsDevelopment of retinotopyBrain wiringPermissive roleMutant miceNeural connectionsOverall activity levelsSpontaneous wavesMice
2013
Competition driven by retinal waves promotes morphological and functional synaptic development of neurons in the superior colliculus
Furman M, Xu HP, Crair MC. Competition driven by retinal waves promotes morphological and functional synaptic development of neurons in the superior colliculus. Journal Of Neurophysiology 2013, 110: 1441-1454. PMID: 23741047, PMCID: PMC3763158, DOI: 10.1152/jn.01066.2012.Peer-Reviewed Original ResearchConceptsSuperior colliculusRetinal wavesRetinal inputBrain slice preparationActivity-dependent competitionWT miceRetinofugal axonsSlice preparationSC neuronsTransgenic miceBrain regionsSynaptic strengthSynaptic developmentSynapse developmentMiceNeuronsEye openingFunctional developmentSynapsesColliculusMolecular mechanismsSpecific roleInstructive roleMorphological developmentAxons
2005
Evidence for an Instructive Role of Retinal Activity in Retinotopic Map Refinement in the Superior Colliculus of the Mouse
Chandrasekaran AR, Plas DT, Gonzalez E, Crair MC. Evidence for an Instructive Role of Retinal Activity in Retinotopic Map Refinement in the Superior Colliculus of the Mouse. Journal Of Neuroscience 2005, 25: 6929-6938. PMID: 16033903, PMCID: PMC6725341, DOI: 10.1523/jneurosci.1470-05.2005.Peer-Reviewed Original ResearchConceptsRetinotopic map refinementRetinal activitySuperior colliculusActivity-dependent factorsNasal-temporal axisSpontaneous retinal activityWild-type miceActivity-dependent cuesActivity-dependent mechanismsRetinotopic map developmentAxon guidance cuesGuidance cuesMolecular mechanismsRetinal wavesPharmacological interventionsMouse modelRetinotopic mapColliculusSame animalsMicePreferential roleReceptive fieldsPhysiological methodsInstructive roleMap refinement