Homeostatic Control of Spontaneous Activity in the Developing Auditory System
Babola TA, Li S, Gribizis A, Lee BJ, Issa JB, Wang HC, Crair MC, Bergles DE. Homeostatic Control of Spontaneous Activity in the Developing Auditory System. Neuron 2018, 99: 511-524.e5. PMID: 30077356, PMCID: PMC6100752, DOI: 10.1016/j.neuron.2018.07.004.Peer-Reviewed Original ResearchConceptsSpiral ganglion neuronsSpontaneous activityAuditory systemDirect neuronal excitationGlutamate releaseEnhanced excitabilityGanglion neuronsUnanesthetized miceSynaptic excitationHearing onsetNeuronal excitationTherapeutic approachesMouse modelSpontaneous burstsCongenital formSynchronized activityHair cellsHomeostatic mechanismsNeuronsHomeostatic controlSimilar frequencyCircuit developmentMiceInfluence developmentDeafness