2008
Neuroprotection via nAChRs: the role of nAChRs in neurodegenerative disorders such as Alzheimer's and Parkinson's disease.
Picciotto MR, Zoli M. Neuroprotection via nAChRs: the role of nAChRs in neurodegenerative disorders such as Alzheimer's and Parkinson's disease. Frontiers In Bioscience-Landmark 2008, 13: 492-504. PMID: 17981563, DOI: 10.2741/2695.Peer-Reviewed Original ResearchMeSH KeywordsAlzheimer DiseaseAnimalsBinding SitesBrainHumansModels, BiologicalNeurodegenerative DiseasesNeuroprotective AgentsNicotineParkinson DiseaseReceptors, NicotinicSignal TransductionConceptsAbility of nicotineNeurodegenerative disordersRole of nAChRsHuman neurodegenerationNeuroprotective agentsParkinson's diseaseDevelopmental stagesCellular effectsNicotine-mediated neuroprotectionRegimen of administrationDrug discoveryNicotine neuroprotectionNeuronal survivalNeuronal deathEpidemiological studiesNicotinic compoundsAlzheimer's diseaseRecent studiesNeuroprotectionDiseaseNicotineCompelling evidenceNAChRsVivoFull understanding
1999
Increased neurodegeneration during ageing in mice lacking high‐affinity nicotine receptors
Zoli M, Picciotto M, Ferrari R, Cocchi D, Changeux J. Increased neurodegeneration during ageing in mice lacking high‐affinity nicotine receptors. The EMBO Journal 1999, 18: 1235-1244. PMID: 10064590, PMCID: PMC1171214, DOI: 10.1093/emboj/18.5.1235.Peer-Reviewed Original ResearchConceptsHigh-affinity nicotine receptorsSpatial learningHippocampal pyramidal neuronsRegion-specific alterationsSerum corticosterone levelsPossible animal modelNicotinic acetylcholine receptorsPyramidal neuronsNeuronal survivalNicotine receptorsCholinergic systemEndocrine parametersControl animalsIncreased neurodegenerationAnimal modelsCorticosterone levelsAcetylcholine receptorsAlzheimer's diseaseDegenerative processCortical regionsMorris mazeCognitive deficitsMutant miceMiceBeta2 subunit