2006
Nicotine‐Mediated Activation of Signal Transduction Pathways
Picciotto M. Nicotine‐Mediated Activation of Signal Transduction Pathways. Novartis Foundation Symposia 2006, 275: 83-95. DOI: 10.1002/9780470029237.ch7.ChaptersCyclic AMP response element binding proteinSignal transductionProtein phosphatase calcineurinSignal transduction pathwaysMAP kinase pathwayActivation of proteinsResponse element-binding proteinElement-binding proteinTranscription factorsPhosphatase calcineurinTransduction pathwaysProtein kinaseKinase pathwayNicotinic acetylcholine receptorsBinding proteinProteinTransductionAcetylcholine receptorsPathwayCalcium entryActivationLong-term changesSynaptic strengthCircuit-level changesKinase
1999
Expression of the transcription factor ΔFosB in the brain controls sensitivity to cocaine
Kelz M, Chen J, Carlezon W, Whisler K, Gilden L, Beckmann A, Steffen C, Zhang Y, Marotti L, Self D, Tkatch T, Baranauskas G, Surmeier D, Neve R, Duman R, Picciotto M, Nestler E. Expression of the transcription factor ΔFosB in the brain controls sensitivity to cocaine. Nature 1999, 401: 272-276. PMID: 10499584, DOI: 10.1038/45790.Peer-Reviewed Original ResearchConceptsNucleus accumbensGlutamate receptor subunit GluR2Locomotor-activating effectsFos family transcription factorsTranscription factor ΔFosBDrugs of abuseΔFosB expressionAcute exposureTransgenic miceChronic exposureSubunit GluR2ΔFosBCocaine addictionAccumbensCocainePersistent expressionTranscription factorsSustained accumulationBrainExposureStable isoformSubset of nucleiExpressionGene expressionMorphine