Nociceptive thresholds are controlled through spinal β2-subunit-containing nicotinic acetylcholine receptors
Yalcin I, Charlet A, Cordero-Erausquin M, Tessier L, Picciotto MR, Schlichter R, Poisbeau P, Freund-Mercier M, Barrot M. Nociceptive thresholds are controlled through spinal β2-subunit-containing nicotinic acetylcholine receptors. Pain 2011, 152: 2131-2137. PMID: 21794985, DOI: 10.1016/j.pain.2011.05.022.Peer-Reviewed Original ResearchConceptsNociceptive thresholdKO miceNicotinic acetylcholine receptorsNociceptive informationMechanical thresholdHigh-frequency transcutaneous electrical nerve stimulationAcetylcholine receptorsTranscutaneous electrical nerve stimulationHigh-frequency TENSInhibitory controlReceptor antagonist bicucullineElectrical nerve stimulationC-fiber stimulationTonic inhibitory controlMechanical nociceptive thresholdThermal nociceptive thresholdInhibitory transmissionAntagonist bicucullineGABAergic controlGABAergic transmissionEndogenous acetylcholineGABAergic inhibitionNerve stimulationNociceptive processingNociceptive responses