The Prototoxin lynx1 Acts on Nicotinic Acetylcholine Receptors to Balance Neuronal Activity and Survival In Vivo
Miwa JM, Stevens TR, King SL, Caldarone BJ, Ibanez-Tallon I, Xiao C, Fitzsimonds RM, Pavlides C, Lester HA, Picciotto MR, Heintz N. The Prototoxin lynx1 Acts on Nicotinic Acetylcholine Receptors to Balance Neuronal Activity and Survival In Vivo. Neuron 2006, 51: 587-600. PMID: 16950157, DOI: 10.1016/j.neuron.2006.07.025.Peer-Reviewed Original ResearchMeSH KeywordsAdaptor Proteins, Signal TransducingAge FactorsAnimalsAssociation LearningBrainCell SurvivalExcitatory Amino Acid AgonistsMembrane GlycoproteinsMembrane PotentialsMiceMice, Mutant StrainsMutationNerve DegenerationNeuronsNeuropeptidesNicotineNicotinic AgonistsPatch-Clamp TechniquesReceptors, NicotinicConceptsNicotinic acetylcholine receptorsNull mutant miceMutant miceAcetylcholine receptorsNeuronal activityNull mutationBiological processesLynx1Calcium levelsAgonist sensitivityReceptor desensitizationSynaptic efficacyMutationsAllosteric modulatorsDesensitization kineticsWide arrayNicotineVivoSpecific testsNAChRsMiceReceptorsSurvivalHyperactivationFunction