Knockout of STriatal enriched protein tyrosine phosphatase in mice results in increased ERK1/2 phosphorylation
Venkitaramani DV, Paul S, Zhang Y, Kurup P, Ding L, Tressler L, Allen M, Sacca R, Picciotto MR, Lombroso PJ. Knockout of STriatal enriched protein tyrosine phosphatase in mice results in increased ERK1/2 phosphorylation. Synapse 2008, 63: 69-81. PMID: 18932218, PMCID: PMC2706508, DOI: 10.1002/syn.20608.Peer-Reviewed Original ResearchConceptsSTEP knockout miceStriatal enriched protein tyrosine phosphataseKnockout miceWild-type miceERK1/2 activityHomozygous knockout miceBrain-specific proteinsExtracellular signal-regulated kinase1/2Wild-type controlsCA2 regionKO miceSTEP protein levelsLateral nucleusCytoarchitectural abnormalitiesSynaptic stimulationCultured neuronsSynaptic plasticityMice resultsHeterozygous miceMiceERK1/2 phosphorylationProtein tyrosine phosphataseProtein levels