Localized low‐level re‐expression of high‐affinity mesolimbic nicotinic acetylcholine receptors restores nicotine‐induced locomotion but not place conditioning
Mineur YS, Brunzell DH, Grady SR, Lindstrom JM, McIntosh JM, Marks MJ, King SL, Picciotto MR. Localized low‐level re‐expression of high‐affinity mesolimbic nicotinic acetylcholine receptors restores nicotine‐induced locomotion but not place conditioning. Genes Brain & Behavior 2009, 8: 257-266. PMID: 19077117, PMCID: PMC2672109, DOI: 10.1111/j.1601-183x.2008.00468.x.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsConditioning, PsychologicalCyclic AMP Response Element-Binding ProteinDopamineGamma-Aminobutyric AcidGene Expression RegulationLocomotionMiceMice, Inbred C57BLMice, TransgenicNicotineNicotinic AgonistsPhosphorylationPresynaptic TerminalsReceptors, NicotinicRewardSynaptosomesTobacco Use DisorderVentral Tegmental AreaConceptsVentral tegmental areaGamma-aminobutyric acidNicotinic acetylcholine receptorsCyclic AMP response element binding proteinTegmental areaPlace preferenceTransgenic miceAcetylcholine receptorsBeta2 knockout micePedunculopontine tegmental areaSystemic nicotine administrationHigh-affinity nAChRsLaterodorsal tegmental nucleusNicotine place preferenceNicotinic partial agonistPlace preference testingDifferent neuronal subtypesAMP response element binding proteinTotal CREB levelsResponse element-binding proteinDA neuronsCholinergic neuronsNicotine administrationSystemic nicotineSmoking cessationNucleus Accumbens CREB Activity is Necessary for Nicotine Conditioned Place Preference
Brunzell DH, Mineur YS, Neve RL, Picciotto MR. Nucleus Accumbens CREB Activity is Necessary for Nicotine Conditioned Place Preference. Neuropsychopharmacology 2009, 34: 1993-2001. PMID: 19212318, PMCID: PMC2709692, DOI: 10.1038/npp.2009.11.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsConditioning, PsychologicalCuesCyclic AMP Response Element-Binding ProteinDecision MakingDose-Response Relationship, DrugDown-RegulationGene Transfer TechniquesMaleMiceMice, Inbred C57BLNicotineNicotinic AgonistsNucleus AccumbensPhosphorylationRewardSynaptic TransmissionTobacco Use DisorderUp-RegulationConceptsCyclic AMP response element binding proteinNAc shellPlace preferenceNicotine CPPCREB activityModulation of cocaineCREB activationNicotine place preferenceAbility of nicotineAbsence of nicotineCue-induced responsesDominant-negative CREB constructNicotinic acetylcholine receptorsAMP response element binding proteinLevels of CREBTranscription factor cyclic AMP response element binding proteinViral-mediated gene transferRange of dosesActivation of intracellularNicotine exposureMorphine rewardC57BL/6J miceNicotine rewardDopamine neuronsLong-term consequences