2015
RNA ligation in neurons by RtcB inhibits axon regeneration
Kosmaczewski SG, Han SM, Han B, Meyer B, Baig HS, Athar W, Lin-Moore AT, Koelle MR, Hammarlund M. RNA ligation in neurons by RtcB inhibits axon regeneration. Proceedings Of The National Academy Of Sciences Of The United States Of America 2015, 112: 8451-8456. PMID: 26100902, PMCID: PMC4500288, DOI: 10.1073/pnas.1502948112.Peer-Reviewed Original ResearchConceptsNerve injuryAxon regenerationUnfolded protein responseProtein responseAxon terminiNeuronsLigationBasal activityInjuryCritical regulatorActivityResponse
2014
The RtcB RNA ligase is an essential component of the metazoan unfolded protein response
Kosmaczewski SG, Edwards TJ, Han SM, Eckwahl MJ, Meyer BI, Peach S, Hesselberth JR, Wolin SL, Hammarlund M. The RtcB RNA ligase is an essential component of the metazoan unfolded protein response. EMBO Reports 2014, 15: 1278-1285. PMID: 25366321, PMCID: PMC4264930, DOI: 10.15252/embr.201439531.Peer-Reviewed Original ResearchConceptsUnfolded protein responseProtein responseRNA ligationIRE-1 branchesMultiple essential processesRNA ligase RtcBXBP-1 mRNACaenorhabditis elegansRNA functionRtcBMRNA fragmentsTarget RNARNA sequencesXBP-1RNA ligaseTRNAEssential processEssential componentMaturationElegansLifespanMutantsLigaseVivo modelXBP1