2016
Inhibiting poly(ADP-ribosylation) improves axon regeneration
Byrne AB, McWhirter RD, Sekine Y, Strittmatter SM, Miller DM, Hammarlund M. Inhibiting poly(ADP-ribosylation) improves axon regeneration. ELife 2016, 5: e12734. PMID: 27697151, PMCID: PMC5050021, DOI: 10.7554/elife.12734.Peer-Reviewed Original ResearchConceptsNovel intrinsic regulatorAxon regenerationDLK functionChemical inhibitionIntrinsic regulatorRegeneration pathwayPARG expressionIntrinsic regenerative potentialDLK signalingCritical functionsPARGRegenerative potentialPARP inhibitorsProteinPARPMammalian cortical neuronsRegenerationMotor neuronsGABA neuronsPolymeraseCortical neuronsSignalingRegulatorSpeciesNeuronsAxon regeneration in C. elegans: Worming our way to mechanisms of axon regeneration
Byrne AB, Hammarlund M. Axon regeneration in C. elegans: Worming our way to mechanisms of axon regeneration. Experimental Neurology 2016, 287: 300-309. PMID: 27569538, PMCID: PMC5136328, DOI: 10.1016/j.expneurol.2016.08.015.Peer-Reviewed Original ResearchConceptsC. elegansC. elegans researchC. elegans modelSimple nervous systemMammalian nervous systemConserved genomeElegansElegans modelRegeneration responseAxon regenerationCellular mechanismsRegeneration researchTransparent bodyNervous systemRegenerationGenomeFundamental questionsSpeciesMechanismTechnical advancesRegeneration studiesPotential future directions
2015
RNA ligation in neurons by RtcB inhibits axon regeneration
Kosmaczewski SG, Han SM, Han B, Meyer B, Baig HS, Athar W, Lin-Moore AT, Koelle MR, Hammarlund M. RNA ligation in neurons by RtcB inhibits axon regeneration. Proceedings Of The National Academy Of Sciences Of The United States Of America 2015, 112: 8451-8456. PMID: 26100902, PMCID: PMC4500288, DOI: 10.1073/pnas.1502948112.Peer-Reviewed Original Research
2014
Syndecan Promotes Axon Regeneration by Stabilizing Growth Cone Migration
Edwards TJ, Hammarlund M. Syndecan Promotes Axon Regeneration by Stabilizing Growth Cone Migration. Cell Reports 2014, 8: 272-283. PMID: 25001284, PMCID: PMC4127196, DOI: 10.1016/j.celrep.2014.06.008.Peer-Reviewed Original ResearchAxon regeneration in C. elegans
Hammarlund M, Jin Y. Axon regeneration in C. elegans. Current Opinion In Neurobiology 2014, 27: 199-207. PMID: 24794753, PMCID: PMC4122601, DOI: 10.1016/j.conb.2014.04.001.Peer-Reviewed Original ResearchInsulin/IGF1 Signaling Inhibits Age-Dependent Axon Regeneration
Byrne AB, Walradt T, Gardner KE, Hubbert A, Reinke V, Hammarlund M. Insulin/IGF1 Signaling Inhibits Age-Dependent Axon Regeneration. Neuron 2014, 81: 561-573. PMID: 24440228, PMCID: PMC3924874, DOI: 10.1016/j.neuron.2013.11.019.Peer-Reviewed Original ResearchMeSH KeywordsAgingAnimalsAnimals, Genetically ModifiedCaenorhabditis elegansCaenorhabditis elegans ProteinsDisease Models, AnimalForkhead Transcription FactorsGene Expression RegulationGreen Fluorescent ProteinsHumansImmunosuppressive AgentsInsulinInsulin-Like Growth Factor INerve DegenerationNerve RegenerationPhosphotransferases (Alcohol Group Acceptor)PTEN PhosphohydrolaseSignal TransductionSirolimusTime FactorsTranscription FactorsAxon Regeneration Genes Identified by RNAi Screening in C. elegans
Nix P, Hammarlund M, Hauth L, Lachnit M, Jorgensen EM, Bastiani M. Axon Regeneration Genes Identified by RNAi Screening in C. elegans. Journal Of Neuroscience 2014, 34: 629-645. PMID: 24403161, PMCID: PMC3870940, DOI: 10.1523/jneurosci.3859-13.2014.Peer-Reviewed Original ResearchConceptsRNAi-based screenCandidate gene screenAnalysis of mutantsGrowth-inhibiting functionComplex molecular eventsCell-intrinsic factorsCaenorhabditis elegansC. elegansAxon regenerationGene candidatesRNAi screeningMembrane dynamicsMAP kinaseΒ-spectrinRegeneration genesGene screenMolecular eventsGenesElegansRobust regenerationMature neuronsMutantsMammalian CNSAntagonistic activityPathway
2012
Neural Regeneration in Caenorhabditis elegans
Bejjani R, Hammarlund M. Neural Regeneration in Caenorhabditis elegans. Annual Review Of Genetics 2012, 46: 499-513. PMID: 22974301, PMCID: PMC3700416, DOI: 10.1146/annurev-genet-110711-155550.Peer-Reviewed Original ResearchNotch Signaling Inhibits Axon Regeneration
Bejjani R, Hammarlund M. Notch Signaling Inhibits Axon Regeneration. Neuron 2012, 73: 268-278. PMID: 22284182, PMCID: PMC3690129, DOI: 10.1016/j.neuron.2011.11.017.Peer-Reviewed Original Research
2009
Axon Regeneration Requires a Conserved MAP Kinase Pathway
Hammarlund M, Nix P, Hauth L, Jorgensen EM, Bastiani M. Axon Regeneration Requires a Conserved MAP Kinase Pathway. Science 2009, 323: 802-806. PMID: 19164707, PMCID: PMC2729122, DOI: 10.1126/science.1165527.Peer-Reviewed Original ResearchMeSH KeywordsAgingAnimalsAxonsAxotomyCaenorhabditis elegansCaenorhabditis elegans ProteinsGamma-Aminobutyric AcidGrowth ConesMAP Kinase Kinase 4MAP Kinase Kinase KinasesMAP Kinase Signaling SystemMitogen-Activated Protein KinasesModels, BiologicalMotor NeuronsMutationNerve RegenerationRNA InterferenceConceptsCell-intrinsic regeneration pathwaysKinase pathwayCaenorhabditis elegans motor neuronsMitogen-activated protein kinase pathwayMAP kinase cascadeMAP kinase pathwayProtein kinase pathwayGrowth cone migrationKinase cascadeRegeneration pathwayCone migrationLater stepsLack of activationDevelopment of therapiesMature neuronsPathwayAplastic statesMost neuronsRegenerationMotor neuronsAxon injuryAxon regenerationNeuron functionActivationNeurons