Endotoxin-induced systemic inflammation activates microglia: [11C]PBR28 positron emission tomography in nonhuman primates
Hannestad J, Gallezot JD, Schafbauer T, Lim K, Kloczynski T, Morris ED, Carson RE, Ding YS, Cosgrove KP. Endotoxin-induced systemic inflammation activates microglia: [11C]PBR28 positron emission tomography in nonhuman primates. NeuroImage 2012, 63: 232-239. PMID: 22776451, PMCID: PMC3699786, DOI: 10.1016/j.neuroimage.2012.06.055.Peer-Reviewed Original ResearchConceptsPositron emission tomographySystemic inflammationMultiple sclerosisInterleukin-6Interleukin-8Translocator proteinEndotoxin-induced systemic inflammationLevels of TSPOEmission tomographyTumor necrosis factor alphaSystemic inflammatory processActivation of microgliaSerum IL-1βIL-6 levelsCourse of diseaseEffects of LPSImportant clinical questionsNecrosis factor alphaInterleukin-1 betaNonhuman primate brainE. coli lipopolysaccharideRegional time-activity dataLocal tissue damageTwo-tissue compartmental modelTotal ligand binding