Naltrexone pretreatment decreases the reinforcing effectiveness of ethanol and saccharin but not PCP or food under concurrent progressive-ratio schedules in rhesus monkeys
Rodefer J, Campbell U, Cosgrove K, Carroll M. Naltrexone pretreatment decreases the reinforcing effectiveness of ethanol and saccharin but not PCP or food under concurrent progressive-ratio schedules in rhesus monkeys. Psychopharmacology 1999, 141: 436-446. PMID: 10090652, DOI: 10.1007/s002130050854.Peer-Reviewed Original ResearchConceptsConcurrent progressive-ratio schedulesProgressive ratio scheduleNaltrexone dosesNaltrexone pretreatmentRhesus monkeysDoses of naltrexoneFood-maintained respondingEffectiveness of drugsSaccharin-maintained respondingNaltrexone antagonismSignificant linear trendEthanol consumptionBaseline levelsNaltrexoneBreak point valuesDosesNon-drug reinforcersEffectiveness of ethanolSelective changesEthanol-maintained respondingDoseMonkeysSaccharin