Featured Publications
Regulation of prefrontal patterning and connectivity by retinoic acid
Shibata M, Pattabiraman K, Lorente-Galdos B, Andrijevic D, Kim SK, Kaur N, Muchnik SK, Xing X, Santpere G, Sousa AMM, Sestan N. Regulation of prefrontal patterning and connectivity by retinoic acid. Nature 2021, 598: 483-488. PMID: 34599305, PMCID: PMC9018119, DOI: 10.1038/s41586-021-03953-x.Peer-Reviewed Original ResearchConceptsPrefrontal cortexRetinoic acidGranular layer 4Neocortex of humansRetinoic acid signalingCerebral cortexRetinoic acid receptorsMotor cortexMotor areaMediodorsal thalamusFetal developmentCortical expansionAcid receptorsGenetic deletionDendritic spinogenesisLayer 4Synthesizing enzymesCortexAcid signalingNeural developmentMiceCritical roleSignalingThalamusSpinogenesis
2023
Molecular and cellular mechanisms of human cortical connectivity
Luria V, Ma S, Shibata M, Pattabiraman K, Sestan N. Molecular and cellular mechanisms of human cortical connectivity. Current Opinion In Neurobiology 2023, 80: 102699. PMID: 36921362, DOI: 10.1016/j.conb.2023.102699.Peer-Reviewed Original Research
2021
Transcriptional network orchestrating regional patterning of cortical progenitors
Ypsilanti AR, Pattabiraman K, Catta-Preta R, Golonzhka O, Lindtner S, Tang K, Jones IR, Abnousi A, Juric I, Hu M, Shen Y, Dickel DE, Visel A, Pennachio LA, Hawrylycz M, Thompson CL, Zeng H, Barozzi I, Nord AS, Rubenstein JL. Transcriptional network orchestrating regional patterning of cortical progenitors. Proceedings Of The National Academy Of Sciences Of The United States Of America 2021, 118: e2024795118. PMID: 34921112, PMCID: PMC8713794, DOI: 10.1073/pnas.2024795118.Peer-Reviewed Original ResearchConceptsRegional patterningEnhancer-gene interactionsTranscription factor networkTF ChIP-seqExpression of hundredsCortical progenitorsVentricular zoneRadial glial stem cellsMutant miceEpigenomic marksTF networksDNA accessibilityGenomic programmingTranscriptional networksGlial stem cellsFactor networkChIP-seqStem cellsVZ cellsPatterningProgenitorsEnhancerMouse cortexExpressionCells
2014
Transcriptional Regulation of Enhancers Active in Protodomains of the Developing Cerebral Cortex
Pattabiraman K, Golonzhka O, Lindtner S, Nord AS, Taher L, Hoch R, Silberberg SN, Zhang D, Chen B, Zeng H, Pennacchio LA, Puelles L, Visel A, Rubenstein JL. Transcriptional Regulation of Enhancers Active in Protodomains of the Developing Cerebral Cortex. Neuron 2014, 82: 989-1003. PMID: 24814534, PMCID: PMC4104757, DOI: 10.1016/j.neuron.2014.04.014.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBinding SitesCerebral CortexCOUP Transcription Factor IEnhancer Elements, GeneticEye ProteinsGene Expression Regulation, DevelopmentalHippocampusHomeodomain ProteinsHumansMiceMice, TransgenicPaired Box Transcription FactorsPAX6 Transcription FactorPre-B-Cell Leukemia Transcription Factor 1Repressor ProteinsTranscription FactorsTranscription, Genetic