Featured Publications
A Comparison between Mouse, In Silico, and Robot Odor Plume Navigation Reveals Advantages of Mouse Odor Tracking
Gumaste A, Coronas-Samano G, Hengenius J, Axman R, Connor EG, Baker KL, Ermentrout B, Crimaldi JP, Verhagen JV. A Comparison between Mouse, In Silico, and Robot Odor Plume Navigation Reveals Advantages of Mouse Odor Tracking. ENeuro 2020, 7: eneuro.0212-19.2019. PMID: 31924732, PMCID: PMC7004486, DOI: 10.1523/eneuro.0212-19.2019.Peer-Reviewed Original ResearchConceptsOdor localizationArduino RobotMinimal algorithmLow complexityTemporal modelNavigationOdor sourceLocalization of odorsComplexityRobust performanceAlgorithmChaotic environmentOdor-based navigationSame environmentEnvironmental complexityEnvironmentRobotPerformanceFast movementsArduinoComplex strategiesSuccessful performanceChaotic natureModel
2023
Spatiotemporal features of neurovascular (un)coupling with stimulus-induced activity and hypercapnia challenge in cerebral cortex and olfactory bulb
James S, Sanggaard S, Akif A, Mishra S, Sanganahalli B, Blumenfeld H, Verhagen J, Hyder F, Herman P. Spatiotemporal features of neurovascular (un)coupling with stimulus-induced activity and hypercapnia challenge in cerebral cortex and olfactory bulb. Cerebrovascular And Brain Metabolism Reviews 2023, 43: 1891-1904. PMID: 37340791, PMCID: PMC10676132, DOI: 10.1177/0271678x231183887.Peer-Reviewed Original ResearchConceptsVasodilatory responseCerebral cortexNeurovascular couplingOlfactory bulbNeuronal activityBrief sensory stimuliRegional neurovascular couplingStimulus-induced activityHypercapnia challengeVascular toneNeuronal deactivationHemodynamic responseNeuronal excitabilityNeuronal responsesCalcium transientsBrain functionHemodynamic signalsSensory stimuliVasodilationHypercapniaCortexMiceCareful appraisalStimuliMetabolic wasteOdor encoding by signals in the olfactory bulb
Verhagen J, Baker K, Vasan G, Pieribone V, Rolls E. Odor encoding by signals in the olfactory bulb. Journal Of Neurophysiology 2023, 129: 431-444. PMID: 36598147, PMCID: PMC9925169, DOI: 10.1152/jn.00449.2022.Peer-Reviewed Original ResearchConceptsOlfactory bulbGlomerular responseMouse dorsalPresynaptic inputsLateral olfactory bulbSet of odorsGlomeruliOlfactory systemOdor identityOdor informationSniff onsetResponse latencyBroad tuningBulbStimulus identityLittle informationPopulationResponseEarly stagesTemporal encodingIndependent responses
2022
Fluorescently-tagged magnetic protein nanoparticles for high-resolution optical and ultra-high field magnetic resonance dual-modal cerebral angiography
Mishra S, Herman P, Crair M, Constable R, Walsh J, Akif A, Verhagen J, Hyder F. Fluorescently-tagged magnetic protein nanoparticles for high-resolution optical and ultra-high field magnetic resonance dual-modal cerebral angiography. Nanoscale 2022, 14: 17770-17788. PMID: 36437785, PMCID: PMC9850399, DOI: 10.1039/d2nr04878g.Peer-Reviewed Original ResearchConceptsProtein nanoparticlesParamagnetic iron oxide nanoparticlesIron oxide nanoparticlesMagnetic resonance imaging (MRI) contrastRelaxivity ratioOxide nanoparticlesRapid renal clearanceNanoparticlesMRI propertiesImaging contrastMRI contrastCitric acidNeuroscience applicationsFluorescent dyeBlood biochemical assaysUnambiguous detectionRelaxivityCerebral angiographyDyePlatformMajor blood vesselsBiochemical assaysTechnologyBrain capillariesFluorescence angiography
2016
The Habituation/Cross‐Habituation Test Revisited: Guidance from Sniffing and Video Tracking
Coronas-Samano G, Ivanova AV, Verhagen JV. The Habituation/Cross‐Habituation Test Revisited: Guidance from Sniffing and Video Tracking. Neural Plasticity 2016, 2016: 9131284. PMID: 27516910, PMCID: PMC4969543, DOI: 10.1155/2016/9131284.Peer-Reviewed Original Research
2015
Direct Behavioral and Neurophysiological Evidence for Retronasal Olfaction in Mice
Rebello MR, Kandukuru P, Verhagen JV. Direct Behavioral and Neurophysiological Evidence for Retronasal Olfaction in Mice. PLOS ONE 2015, 10: e0117218. PMID: 25675095, PMCID: PMC4326425, DOI: 10.1371/journal.pone.0117218.Peer-Reviewed Original ResearchConceptsOlfactory bulbMouse's abilityAdditional animal modelsHead-fixed miceConcentration-dependent mannerAnesthetized ratsAwake miceRetronasal odorantsRetronasal odorCalcium responseAnimal modelsTransgenic miceMiceRatsRetronasal olfactionGo behavioral taskRetronasal smellLick spoutFood flavor perceptionNeurophysiological evidenceBehavioral tasksHuman flavor perceptionFood selectionOlfactionBulbectomy