Fus1 KO Mouse As a Model of Oxidative Stress-Mediated Sporadic Alzheimer's Disease: Circadian Disruption and Long-Term Spatial and Olfactory Memory Impairments
Coronas-Samano G, Baker KL, Tan WJ, Ivanova AV, Verhagen JV. Fus1 KO Mouse As a Model of Oxidative Stress-Mediated Sporadic Alzheimer's Disease: Circadian Disruption and Long-Term Spatial and Olfactory Memory Impairments. Frontiers In Aging Neuroscience 2016, 8: 268. PMID: 27895577, PMCID: PMC5108791, DOI: 10.3389/fnagi.2016.00268.Peer-Reviewed Original ResearchSporadic Alzheimer's diseaseKO miceOxidative stressAlzheimer's diseaseYounger ageWT adult miceOlfactory memory impairmentsEffective therapeutic treatmentMore sleep timeClear deficitNeurobehavioral deficitsRisk factorsAD hallmarksMetabolic dysregulationOlfactory bulbAdult miceAnimal modelsSleep timeEarly interventionMemory impairmentAD etiologyPharmacological targetsTherapeutic treatmentCircadian disruptionMice