2017
Selective synaptic connections in the retinal pathway for night vision
Beaudoin DL, Kupershtok M, Demb JB. Selective synaptic connections in the retinal pathway for night vision. The Journal Of Comparative Neurology 2017, 527: 117-132. PMID: 28856684, PMCID: PMC5832573, DOI: 10.1002/cne.24313.Peer-Reviewed Original ResearchMeSH KeywordsAmacrine CellsAnimalsGuinea PigsNeural PathwaysNight VisionRetinal Ganglion CellsSynapsesConceptsAII amacrine cellsRetinal ganglion cellsAmacrine cellsRGC typesBipolar terminalsSynaptic connectionsCertain retinal ganglion cellsConnected retinal ganglion cellsIonotropic glutamate receptor antagonistsOFF alpha cellsGlutamate receptor antagonistsInner plexiform layerBipolar cell terminalsSelective synaptic connectionsBipolar cell activityOFF alphaRetinal connectionsRetinal pathwaysPlexiform layerReceptor antagonistDirect synapsesGanglion cellsGlycinergic synapsesInhibitory currentsMammalian retina
2014
NMDA and AMPA receptors contribute similarly to temporal processing in mammalian retinal ganglion cells
Stafford BK, Manookin MB, Singer JH, Demb JB. NMDA and AMPA receptors contribute similarly to temporal processing in mammalian retinal ganglion cells. The Journal Of Physiology 2014, 592: 4877-4889. PMID: 25217374, PMCID: PMC4259533, DOI: 10.1113/jphysiol.2014.276543.Peer-Reviewed Original ResearchConceptsGanglion cellsNMDAR kineticsOFF alphaMammalian retinal ganglion cellsNMDA-type glutamate receptorsAMPAR-mediated responsesOFF alpha cellsGanglion cell typesRetinal ganglion cellsGuinea pig retinaNMDAR-mediated responsesBipolar cell pathwaysCell typesFast excitatory neurotransmissionGlutamatergic transmissionPresynaptic inhibitionGlutamate releaseSame synapsesSynaptic inhibitionGlutamate receptorsHz stimulationPostsynaptic AMPAExcitatory neurotransmissionSensory neuronsAMPA receptors
2011
Delayed-Rectifier K Channels Contribute to Contrast Adaptation in Mammalian Retinal Ganglion Cells
Weick M, Demb JB. Delayed-Rectifier K Channels Contribute to Contrast Adaptation in Mammalian Retinal Ganglion Cells. Neuron 2011, 71: 166-179. PMID: 21745646, PMCID: PMC3134798, DOI: 10.1016/j.neuron.2011.04.033.Peer-Reviewed Original ResearchConceptsRetinal ganglion cellsGanglion cellsSubsequent depolarizationContrast adaptationOFF alpha ganglion cellsMammalian retinal ganglion cellsAlpha ganglion cellsGuinea pig retinaK channelsSuppress excitabilityPig retinaNa channel inactivationFiring responsesBrief depolarizationBrief hyperpolarizationRectifier K channelsVisual stimulationSomatic membrane patchesChannel inactivationDepolarizationPhysiological rangeIntrinsic mechanismHyperpolarizationCellsSalamander cells
2010
NMDA Receptor Contributions to Visual Contrast Coding
Manookin MB, Weick M, Stafford BK, Demb JB. NMDA Receptor Contributions to Visual Contrast Coding. Neuron 2010, 67: 280-293. PMID: 20670835, PMCID: PMC2913150, DOI: 10.1016/j.neuron.2010.06.020.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsContrast SensitivityDizocilpine MaleateElectric ConductivityExcitatory Amino Acid AgonistsExcitatory Amino Acid AntagonistsGene Expression RegulationGuinea PigsIn Vitro TechniquesLightMiceMice, Inbred C57BLN-MethylaspartatePatch-Clamp TechniquesPhotic StimulationPiperidinesReceptors, N-Methyl-D-AspartateRetinaRetinal Ganglion CellsVisual PerceptionConceptsNMDA receptorsOFF alphaAlpha cellsNMDA-type glutamate receptorsOFF alpha cellsDelta cellsGanglion cell typesNMDA receptor contributionCell typesExcitatory responsesGlutamate receptorsInhibitory currentsAMPA receptorsReceptor contributionGluN2B subunitContrast sensitivityContrast codingReceptorsNMDAAMPACertain cell typesCellsVisual processingAlpha
2008
Distinct expressions of contrast gain control in parallel synaptic pathways converging on a retinal ganglion cell
Beaudoin DL, Manookin MB, Demb JB. Distinct expressions of contrast gain control in parallel synaptic pathways converging on a retinal ganglion cell. The Journal Of Physiology 2008, 586: 5487-5502. PMID: 18832424, PMCID: PMC2655385, DOI: 10.1113/jphysiol.2008.156224.Peer-Reviewed Original ResearchConceptsCone bipolar cellsOFF ganglion cellsRod bipolar cellsGanglion cellsRetinal ganglion cellsBipolar cellsInhibitory inputsExcitatory inputsSynaptic pathwaysContrast gain controlOFF cone bipolar cellsIonotropic glutamate receptor antagonistsY-type ganglion cellsRod bipolar pathwayAII amacrine cellsGlutamate receptor antagonistsGanglion cell firingWhole-cell recordingsLoose-patch recordingsAmacrine cellsReceptor antagonistRetinal pathwaysAII cellsSynaptic mechanismsSynaptic currentsDisinhibition Combines with Excitation to Extend the Operating Range of the OFF Visual Pathway in Daylight
Manookin MB, Beaudoin DL, Ernst ZR, Flagel LJ, Demb JB. Disinhibition Combines with Excitation to Extend the Operating Range of the OFF Visual Pathway in Daylight. Journal Of Neuroscience 2008, 28: 4136-4150. PMID: 18417693, PMCID: PMC2557439, DOI: 10.1523/jneurosci.4274-07.2008.Peer-Reviewed Original ResearchConceptsOFF ganglion cellsAII amacrine cellsCone bipolar cellsGanglion cellsAmacrine cellsAII cellsBipolar cellsPresence of CNQXBipolar cell synapsesD-APOFF visual pathwayBipolar cell pathwaysGap junctionsGlycine releaseExcitatory responsesIonotropic glutamateSynaptic inhibitionCell synapsesON pathwayGlycine receptorsLight decrementsVisual pathwayElectrical synapsesMeclofenamic acidDaylight vision
2007
Functional Circuitry for Peripheral Suppression in Mammalian Y-Type Retinal Ganglion Cells
Zaghloul KA, Manookin MB, Borghuis BG, Boahen K, Demb JB. Functional Circuitry for Peripheral Suppression in Mammalian Y-Type Retinal Ganglion Cells. Journal Of Neurophysiology 2007, 97: 4327-4340. PMID: 17460102, DOI: 10.1152/jn.01091.2006.Peer-Reviewed Original ResearchConceptsAmacrine cellsGanglion cellsCenter responseSynaptic layersY-type retinal ganglion cellsHorizontal cellsY-type ganglion cellsSecond synaptic layerGanglion cell receptive fieldsRetinal ganglion cellsGuinea pig retinaStimulus-response curvesRetinal ganglion cell receptive fieldsFirst synaptic layerCurrent-clamp conditionsBipolar terminalsGlutamate releaseCell receptive fieldsPeripheral gratingsPeripheral suppressionIntracellular recordingsPig retinaSubthreshold membrane potentialsExcitatory centerInhibitory conductanceCellular Basis for Contrast Gain Control over the Receptive Field Center of Mammalian Retinal Ganglion Cells
Beaudoin DL, Borghuis BG, Demb JB. Cellular Basis for Contrast Gain Control over the Receptive Field Center of Mammalian Retinal Ganglion Cells. Journal Of Neuroscience 2007, 27: 2636-2645. PMID: 17344401, PMCID: PMC6672510, DOI: 10.1523/jneurosci.4610-06.2007.Peer-Reviewed Original ResearchConceptsReceptive field centerPresynaptic bipolar cellsGanglion cellsBipolar cellsAmacrine cellsGanglion cell receptive field centersContrast gain controlMammalian retinal ganglion cellsMammalian ganglion cellsRetinal ganglion cellsWhole-cell recordingsInhibitory neurotransmitter receptorsField centerVoltage-clamp conditionsInhibitory interneuronsSynaptic releaseNeurotransmitter receptorsCenter responseExtracellular recordingsPharmacological conditionsAdequate stimulationInhibitory conductanceCalcium bufferingSubthreshold responsesMembrane currents
2006
Presynaptic Mechanism for Slow Contrast Adaptation in Mammalian Retinal Ganglion Cells
Manookin MB, Demb JB. Presynaptic Mechanism for Slow Contrast Adaptation in Mammalian Retinal Ganglion Cells. Neuron 2006, 50: 453-464. PMID: 16675399, DOI: 10.1016/j.neuron.2006.03.039.Peer-Reviewed Original ResearchMeSH KeywordsAction PotentialsAdaptation, PhysiologicalAnimalsCalcium ChannelsContrast SensitivityGlutamic AcidGuinea PigsOrgan Culture TechniquesPhotic StimulationPresynaptic TerminalsReaction TimeReceptors, GABAReceptors, GlycineReceptors, Metabotropic GlutamateRetinal Bipolar CellsRetinal Ganglion CellsSynaptic TransmissionConceptsPresynaptic bipolar cellsRetinal ganglion cellsGanglion cellsBipolar cellsMammalian retinal ganglion cellsSlow contrast adaptationReduced glutamate releaseIntrinsic cellular propertiesIntrinsic cellular mechanismsCortical adaptationGlutamate releasePresynaptic mechanismsGlycine receptorsVisual neuronsAfterhyperpolarizationExcitatory conductancePotassium conductanceContrast adaptationCellular mechanismsCortical cellsNeuronsCellsCellular propertiesMGluRsSpatial stimuli
2005
Contrast Adaptation in Subthreshold and Spiking Responses of Mammalian Y-Type Retinal Ganglion Cells
Zaghloul KA, Boahen K, Demb JB. Contrast Adaptation in Subthreshold and Spiking Responses of Mammalian Y-Type Retinal Ganglion Cells. Journal Of Neuroscience 2005, 25: 860-868. PMID: 15673666, PMCID: PMC6725633, DOI: 10.1523/jneurosci.2782-04.2005.Peer-Reviewed Original ResearchConceptsRetinal ganglion cellsGanglion cellsIntracellular recordingsSubthreshold responsesY-type retinal ganglion cellsY-type ganglion cellsSynaptic mechanismsSynaptic inputsMammalian retinaSpiking responseExtracellular recordingsSubthreshold potentialsContrast sensitivitySpike outputSpike thresholdContrast adaptationSpike generationGain changesCellsRecordingsResponseApparent reductionRecording conditionsAbove effectsMean light level
2004
How Retinal Ganglion Cells Prevent Synaptic Noise From Reaching the Spike Output
Demb JB, Sterling P, Freed MA. How Retinal Ganglion Cells Prevent Synaptic Noise From Reaching the Spike Output. Journal Of Neurophysiology 2004, 92: 2510-2519. PMID: 15175375, DOI: 10.1152/jn.00108.2004.Peer-Reviewed Original ResearchConceptsSynaptic convergenceSpike outputGanglion cellsIntracellular recordingsSynaptic inputsSpike responsesF1 responseRetinal ganglion cellsSpike rateNeuron synaptic inputsPrimary visual cortexExtracellular recordingsVisual cortexPeak depolarizationStimulus frequencyStimulus cycleSynaptic vesiclesStimulus contrastStrong stimulusSynaptic noiseDepolarizationNeuronsParadoxical findingsMembrane potentialSame cells
2003
Different Circuits for ON and OFF Retinal Ganglion Cells Cause Different Contrast Sensitivities
Zaghloul KA, Boahen K, Demb JB. Different Circuits for ON and OFF Retinal Ganglion Cells Cause Different Contrast Sensitivities. Journal Of Neuroscience 2003, 23: 2645-2654. PMID: 12684450, PMCID: PMC6742092, DOI: 10.1523/jneurosci.23-07-02645.2003.Peer-Reviewed Original ResearchConceptsOFF cellsGanglion cellsSynaptic inputsContrast sensitivityExcitatory conductanceOFF retinal ganglion cellsOFF ganglion cellsBasal glutamate releaseRetinal ganglion cellsBrisk-transient cellsGuinea pig retinaBipolar terminalsPresynaptic circuitsGlutamate releaseIntracellular recordingsON pathwayPig retinaSubthreshold membrane potentialsLight incrementsL-APMembrane potentialCellsMean luminancePathwayRetina
2001
Cellular Basis for the Response to Second-Order Motion Cues in Y Retinal Ganglion Cells
Demb J, Zaghloul K, Sterling P. Cellular Basis for the Response to Second-Order Motion Cues in Y Retinal Ganglion Cells. Neuron 2001, 32: 711-721. PMID: 11719210, DOI: 10.1016/s0896-6273(01)00484-6.Peer-Reviewed Original ResearchConceptsGanglion cellsEPSP/IPSP sequencesY cellsOFF ganglion cellsY ganglion cellsRetinal ganglion cellsSecond-order motion cuesSecond-order motion stimuliDendritic fieldsInhibitory effectCell inhibitionCellular basisMotion stimuliCortical cellsSecond-order motionCellsPerceive motionResponseTetrodotoxinCortexRetinaBipolar Cells Contribute to Nonlinear Spatial Summation in the Brisk-Transient (Y) Ganglion Cell in Mammalian Retina
Demb J, Zaghloul K, Haarsma L, Sterling P. Bipolar Cells Contribute to Nonlinear Spatial Summation in the Brisk-Transient (Y) Ganglion Cell in Mammalian Retina. Journal Of Neuroscience 2001, 21: 7447-7454. PMID: 11567034, PMCID: PMC6762908, DOI: 10.1523/jneurosci.21-19-07447.2001.Peer-Reviewed Original ResearchConceptsBipolar cellsGanglion cellsBrisk-transient ganglion cellsReceptive fieldsExcitatory postsynaptic potentialsGuinea pig retinaNonlinear spatial summationNonlinear receptive fieldsAmacrine cellsPostsynaptic potentialsPig retinaExcitatory mechanismsMammalian retinaY cellsLinear receptive fieldsSpatial summationBipolar inputRetinaCellsPeripheral componentsCentral componentAcetylcholineTetrodotoxinGABA
1999
Functional Circuitry of the Retinal Ganglion Cell's Nonlinear Receptive Field
Demb J, Haarsma L, Freed M, Sterling P. Functional Circuitry of the Retinal Ganglion Cell's Nonlinear Receptive Field. Journal Of Neuroscience 1999, 19: 9756-9767. PMID: 10559385, PMCID: PMC6782950, DOI: 10.1523/jneurosci.19-22-09756.1999.Peer-Reviewed Original ResearchConceptsGanglion cellsDendritic fieldsContrast-reversing gratingsNonlinear receptive fieldsOFF ganglion cellsReceptive fieldsCell dendritic fieldsRetinal ganglion cellsGuinea pig retinaBipolar cell responsesReceptive field mechanismsSurround responsesBipolar cellsPig retinaCell responsesFunctional circuitryL-APVisual stimuliMembrane potentialSingle classCellsResponseInterneuronsTetrodotoxinRetina