2024
The Structural and Functional Integrity of Rod Photoreceptor Ribbon Synapses Depends on Redundant Actions of Dynamins 1 and 3
Hanke-Gogokhia C, Zapadka T, Finkelstein S, Klingeborn M, Maugel T, Singer J, Arshavsky V, Demb J. The Structural and Functional Integrity of Rod Photoreceptor Ribbon Synapses Depends on Redundant Actions of Dynamins 1 and 3. Journal Of Neuroscience 2024, 44: e1379232024. PMID: 38641407, PMCID: PMC11209669, DOI: 10.1523/jneurosci.1379-23.2024.Peer-Reviewed Original ResearchRod ribbon synapsesDynamin-1Photoreceptor ribbon synapsesDynamin isoformsMembrane scissionRibbon synapsesConventional synapsesReduced synaptic vesicle densitySynaptic vesicle recycling processesEndocytosis of synaptic vesiclesRibbon-type active zonesVesicle densityConditional gene knockout approachGene knockout approachSynaptic vesicle densityVesicle endocytosisVesicle cycleDisrupt endocytosisDynaminSpecialized proteinsSynapse integrityEnlarged vesiclesSynaptic vesiclesKnockout approachRod photoreceptors
2004
How Retinal Ganglion Cells Prevent Synaptic Noise From Reaching the Spike Output
Demb JB, Sterling P, Freed MA. How Retinal Ganglion Cells Prevent Synaptic Noise From Reaching the Spike Output. Journal Of Neurophysiology 2004, 92: 2510-2519. PMID: 15175375, DOI: 10.1152/jn.00108.2004.Peer-Reviewed Original ResearchConceptsSynaptic convergenceSpike outputGanglion cellsIntracellular recordingsSynaptic inputsSpike responsesF1 responseRetinal ganglion cellsSpike rateNeuron synaptic inputsPrimary visual cortexExtracellular recordingsVisual cortexPeak depolarizationStimulus frequencyStimulus cycleSynaptic vesiclesStimulus contrastStrong stimulusSynaptic noiseDepolarizationNeuronsParadoxical findingsMembrane potentialSame cells