2023
Brn3b regulates the formation of fear-related midbrain circuits and defensive responses to visual threat
Lee H, Weinberg-Wolf H, Lee H, Lee T, Conte J, Godoy-Parejo C, Demb J, Rudenko A, Kim IJ. Brn3b regulates the formation of fear-related midbrain circuits and defensive responses to visual threat. PLOS Biology 2023, 21: e3002386. PMID: 37983249, PMCID: PMC10695396, DOI: 10.1371/journal.pbio.3002386.Peer-Reviewed Original ResearchConceptsTranscription factor Brn3bLoss of neuronsVisual threatLateral posterior nucleusMutant mice displayDefensive responsesDefensive freezing responsesPosterior nucleusTachykinin 2Mice displayMidbrain circuitVisual circuitsNeural circuitryBrn3bSpecific genetic componentsFreezing responseFear-associated behaviorsSocial isolationTac2Behavioral phenotypesMolecular mechanismsFunctional organizationGenetic componentResponseSimilar mechanism
2015
Functional Circuitry of the Retina
Demb JB, Singer JH. Functional Circuitry of the Retina. Annual Review Of Vision Science 2015, 1: 263-289. PMID: 28532365, PMCID: PMC5749398, DOI: 10.1146/annurev-vision-082114-035334.Peer-Reviewed Original ResearchGanglion cellsImportant model systemCell typesSynaptic excitationMammalian retinaParallel pathwaysMouse retinaModel systemNeural circuitryFunctional circuitryRetinaRetinal computationCellular compositionOutput neuronsBasic mechanismsApparent complexityDynamic balanceCellsStraightforward mechanismSpeciesPathwayInterneuronsMechanismNeuronsBrain
2013
Transsynaptic Tracing with Vesicular Stomatitis Virus Reveals Novel Retinal Circuitry
Beier KT, Borghuis BG, El-Danaf RN, Huberman AD, Demb JB, Cepko CL. Transsynaptic Tracing with Vesicular Stomatitis Virus Reveals Novel Retinal Circuitry. Journal Of Neuroscience 2013, 33: 35-51. PMID: 23283320, PMCID: PMC3711516, DOI: 10.1523/jneurosci.0245-12.2013.Peer-Reviewed Original ResearchConceptsStarburst amacrine cellsVesicular stomatitis virusDirection-selective retinal ganglion cellsRetinal ganglion cell typesGanglion cell typesRetinal ganglion cellsStomatitis virusCell typesDensity of neuropilTranssynaptic tracerNeurotropic virusesPresynaptic sourceAmacrine cellsSynaptic relationshipsGanglion cellsRetinal circuitryPostsynaptic neuronsSynaptic partnersMouse retinaViral tracersCell type-specific dissectionNeural circuitsNeural circuitryViral spreadVirus
2010
Neurons show their true colours
Demb JB, Brainard DH. Neurons show their true colours. Nature 2010, 467: 670-671. PMID: 20930837, DOI: 10.1038/467670b.Peer-Reviewed Original Research