2020
Ketamine and rapid acting antidepressants: Are we ready to cure, rather than treat depression?
Abdallah CG, Krystal JH. Ketamine and rapid acting antidepressants: Are we ready to cure, rather than treat depression? Behavioural Brain Research 2020, 390: 112628. PMID: 32407817, PMCID: PMC7316409, DOI: 10.1016/j.bbr.2020.112628.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAntidepressive AgentsDepressive DisorderKetamineNeuronal PlasticitySecondary PreventionStress, PsychologicalConceptsChronic stress pathologyRapid acting antidepressantsHigh treatment resistanceActing antidepressantsChronic courseClinical evidenceLeading causeTreatment resistancePsychiatric disordersStress pathologyDepressionLarge proportionAntidepressantsPatientsReviewKetamineIllnessPathologyComprehensive reviewResponding to the hidden pandemic for healthcare workers: stress
Krystal JH. Responding to the hidden pandemic for healthcare workers: stress. Nature Medicine 2020, 26: 639-639. PMID: 32350461, DOI: 10.1038/s41591-020-0878-4.Peer-Reviewed Original Research
2016
Glutamate dysregulation and glutamatergic therapeutics for PTSD: Evidence from human studies
Averill LA, Purohit P, Averill CL, Boesl MA, Krystal JH, Abdallah CG. Glutamate dysregulation and glutamatergic therapeutics for PTSD: Evidence from human studies. Neuroscience Letters 2016, 649: 147-155. PMID: 27916636, PMCID: PMC5482215, DOI: 10.1016/j.neulet.2016.11.064.Peer-Reviewed Original ResearchMeSH KeywordsBrainGamma-Aminobutyric AcidGlutamic AcidHumansReceptors, GlutamateStress Disorders, Post-TraumaticStress, PsychologicalSynaptic TransmissionConceptsPosttraumatic stress disorderPsychiatric disordersStress-related psychiatric disordersAlternative pharmacologic treatmentsPutative neurobiological underpinningsGlutamate-modulating agentsTrauma-related disordersGlutamatergic abnormalitiesGlutamate dysregulationPharmacologic treatmentPharmacologic interventionsGlutamatergic functionGlutamate neurotransmissionMillions of individualsHuman studiesCardinal featuresStress disorderDisordersNeurobiological underpinningsRelated future directionsEvidenceChronicDysfunctionNeurotransmissionSubject dataSynaptic plasticity and depression: new insights from stress and rapid-acting antidepressants
Duman RS, Aghajanian GK, Sanacora G, Krystal JH. Synaptic plasticity and depression: new insights from stress and rapid-acting antidepressants. Nature Medicine 2016, 22: 238-249. PMID: 26937618, PMCID: PMC5405628, DOI: 10.1038/nm.4050.Peer-Reviewed Original ResearchMeSH KeywordsAntidepressive AgentsBrain-Derived Neurotrophic FactorCytokinesDepressive DisorderDiabetes MellitusExcitatory Amino Acid AntagonistsFemaleGlucocorticoidsHumansHypothalamo-Hypophyseal SystemInflammationKetamineMaleNeuronal PlasticityPituitary-Adrenal SystemSelective Serotonin Reuptake InhibitorsSex FactorsSignal TransductionStress, PsychologicalTime Factors
2011
Insomnia, Nightmare Frequency, and Nightmare Distress in Victims of Sexual Abuse
Steine IM, Krystal JH, Nordhus IH, Bjorvatn B, Harvey AG, Eid J, Grønli J, Milde AM, Pallesen S. Insomnia, Nightmare Frequency, and Nightmare Distress in Victims of Sexual Abuse. Journal Of Interpersonal Violence 2011, 27: 1827-1843. PMID: 22204947, DOI: 10.1177/0886260511430385.Peer-Reviewed Original Research
2010
A Prospective Cohort Study Investigating Factors Associated With Depression During Medical Internship
Sen S, Kranzler HR, Krystal JH, Speller H, Chan G, Gelernter J, Guille C. A Prospective Cohort Study Investigating Factors Associated With Depression During Medical Internship. JAMA Psychiatry 2010, 67: 557-565. PMID: 20368500, PMCID: PMC4036806, DOI: 10.1001/archgenpsychiatry.2010.41.Peer-Reviewed Original ResearchMeSH KeywordsAdultCohort StudiesDepressionDepressive DisorderDepressive Disorder, MajorFemaleGenotypeHealth StatusHumansInternship and ResidencyLife Change EventsMaleMedicinePolymorphism, Single NucleotidePrevalenceProspective StudiesRisk FactorsSerotonin Plasma Membrane Transport ProteinsStress, PsychologicalStudents, MedicalSurveys and QuestionnairesConceptsDepressive symptomsPHQ-9 depression scoresProspective cohort studyPrevalence of depressionPatient Health QuestionnaireProportion of participantsMedical internsMedical internshipGreater increasePHQ-9 criteriaCohort studyHealth QuestionnaireMood symptomsGeneral populationDepression scoresUS hospitalsSymptomsSerotonin transporter protein geneGenetic polymorphismsDepressionGenetic factorsLife stressMarked increaseRecent reportsResidency programs
2009
Noradrenergic and serotonergic mechanisms in the neurobiology of posttraumatic stress disorder and resilience
Krystal JH, Neumeister A. Noradrenergic and serotonergic mechanisms in the neurobiology of posttraumatic stress disorder and resilience. Brain Research 2009, 1293: 13-23. PMID: 19332037, PMCID: PMC2761677, DOI: 10.1016/j.brainres.2009.03.044.Peer-Reviewed Original ResearchConceptsPosttraumatic stress disorderStress disorderOrdinary stressful life eventsEtiology of PTSDNeurobiology of PTSDSymptoms of PTSDImpact of traumaStressful life eventsTraumatic eventsNeurobiological systemsLife eventsTreatment developmentSerotonergic mechanismsNeurobiologyUse of antidepressantsDevelopment of treatmentsBasic researchResilienceMonoaminergic mechanismsAvailable treatmentsRelevant findingsHyperarousalResearchDisordersPsychopathology
1996
Neural Mechanisms in dissociative amnesia for childhood abuse: relevance to the current controversy surrounding the "false memory syndrome"
Bremner JD, Krystal JH, Charney DS, Southwick SM. Neural Mechanisms in dissociative amnesia for childhood abuse: relevance to the current controversy surrounding the "false memory syndrome". American Journal Of Psychiatry 1996, 153: 71-82. PMID: 8659644, DOI: 10.1176/ajp.153.7.71.Peer-Reviewed Original ResearchConceptsFalse memory syndromeMemory tracesChildhood abuseDissociative amnesiaEffects of stressMemory functionMemory syndromeNeurobiology of memoryBrain regionsNormal memory functionChildren's memoryTraumatic stressorsSpecific brain regionsNeural mechanismsStressful eventsMemoryAmnesiaExtreme stressBrain chemistryAbuseRecallPsychiatric disordersLong-term alterationsLong-term effectsNormal personsNoradrenergic mechanisms in stress and anxiety: I. preclinical studies
Bremner J, Krystal J, Southwick S, Charney D. Noradrenergic mechanisms in stress and anxiety: I. preclinical studies. Synapse 1996, 23: 28-38. PMID: 8723133, DOI: 10.1002/(sici)1098-2396(199605)23:1<28::aid-syn4>3.0.co;2-j.Peer-Reviewed Original ResearchConceptsPost-traumatic stress disorderBrain regionsNoradrenergic brain systemsMultiple subcortical areasConsiderable preclinical evidenceLocus coeruleusBrain systemsNeural mechanismsStress disorderTarget brain regionsBehavioral manifestationsBrain functionPanic disorderStress exposureChronic stress resultsTurnover of norepinephrineSubcortical areasAnxietyPsychiatric disordersNoradrenergic systemLong-term alterationsNoradrenergic mechanismsNoradrenergic neuronsNorepinephrine releasePreclinical evidenceNoradrenergic mechanisms in stress and anxiety: II. Clinical studies
Bremner J, Krystal J, Southwick S, Charney D. Noradrenergic mechanisms in stress and anxiety: II. Clinical studies. Synapse 1996, 23: 39-51. PMID: 8723134, DOI: 10.1002/(sici)1098-2396(199605)23:1<39::aid-syn5>3.0.co;2-i.Peer-Reviewed Original ResearchConceptsPosttraumatic stress disorderBlood pressureNoradrenergic functionHeart rateNoradrenergic systemClinical studiesAdrenergic receptorsPanic disorderAnxiety disordersGrowth hormone responseMeasurement of norepinephrineNorepinephrine responseNoradrenergic mechanismsBaseline norepinephrineNoradrenergic responsivenessPharmacological challengeCatecholaminergic functionHormone responseTraumatic remindersPatientsAcute stressorStress disorderNorepinephrineBaseline measuresConsistent finding
1995
Functional neuroanatomical correlates of the effects of stress on memory
Bremner J, Krystal J, Southwick S, Charney D. Functional neuroanatomical correlates of the effects of stress on memory. Journal Of Traumatic Stress 1995, 8: 527-553. PMID: 8564272, DOI: 10.1002/jts.2490080403.Peer-Reviewed Original ResearchConceptsPosttraumatic stress disorderEffects of stressBrain regionsTraumatic stressNeural mechanismsSymptoms of PTSDFalse memory syndromeFunctional neuroanatomical correlatesFear conditioningNeurobiological approachStress disorderDissociative amnesiaMemory syndromeStress sensitizationNeuroanatomical correlatesMemory functionChildhood memoriesMemoryStress-induced alterationsImplicationsAmnesiaPsychotherapyCorrelatesConditioningSymptoms
1993
Psychobiologic Mechanisms of Posttraumatic Stress Disorder
Charney DS, Deutch AY, Krystal JH, Southwick SM, Davis M. Psychobiologic Mechanisms of Posttraumatic Stress Disorder. JAMA Psychiatry 1993, 50: 294-305. PMID: 8466391, DOI: 10.1001/archpsyc.1993.01820160064008.Peer-Reviewed Original ResearchConceptsPosttraumatic stress disorderStress disorderPathophysiology of PTSDAvoidance of stimuliFailure of extinctionFear conditioningTraumatic memoriesMemory processesAutonomic hyperarousalTraumatic eventsEffects of stressCore symptomsPersistent reexperiencingPsychobiologic mechanismsAdaptive behavioralBrain structuresNeurochemical systemsNeurobiologic mechanismsReexperiencingParallel activationHyperarousalDisordersChronic courseTrauma resultsBehavioral sensitization