2023
Psychosocial moderators of polygenic risk scores of inflammatory biomarkers in relation to GrimAge
Tamman A, Koller D, Nagamatsu S, Cabrera-Mendoza B, Abdallah C, Krystal J, Gelernter J, Montalvo-Ortiz J, Polimanti R, Pietrzak R. Psychosocial moderators of polygenic risk scores of inflammatory biomarkers in relation to GrimAge. Neuropsychopharmacology 2023, 49: 699-708. PMID: 37848731, PMCID: PMC10876568, DOI: 10.1038/s41386-023-01747-5.Peer-Reviewed Original ResearchPolygenic risk scoresRisk scoreGenetic predispositionModifiable psychosocial variablesAge-related morbidityGamma-glutamyl transferaseInflammatory biomarkersSystemic inflammationNational HealthApolipoprotein BMale veteransPsychosocial factorsVeterans StudySaliva samplesPsychosocial moderatorsPsychosocial variablesAntihistamine drugsMilitary veteransGrimAgeGrimAge accelerationInflammationUK BiobankDrugsRepresentative samplePredispositionLongitudinal Trends in Suicidal Thoughts and Behaviors Among US Military Veterans During the COVID-19 Pandemic
Fischer I, Nichter B, Na P, Norman S, Krystal J, Pietrzak R. Longitudinal Trends in Suicidal Thoughts and Behaviors Among US Military Veterans During the COVID-19 Pandemic. JAMA Psychiatry 2023, 80: 577-584. PMID: 37017978, PMCID: PMC10077136, DOI: 10.1001/jamapsychiatry.2023.0393.Peer-Reviewed Original ResearchConceptsNew-onset suicidal ideationUS military veteransLifetime substance use disorderPast-year suicidal ideationSubstance use disordersSuicidal ideationSuicide planningMilitary veteransUse disordersPsychiatric distressCOVID-19 pandemicSuicidal thoughtsPopulation-based longitudinal studyEvidence-based preventionLongitudinal studyLongitudinal trendsCohort studyNational HealthUS veteransMAIN OUTCOMEVeterans StudySuicide attemptsSuicide riskVulnerable populationsVeteransTrajectories of alcohol consumption in U.S. military veterans: Results from a 10-year population-based longitudinal study
Na P, Montalvo-Ortiz J, Petrakis I, Krystal J, Polimanti R, Gelernter J, Pietrzak R. Trajectories of alcohol consumption in U.S. military veterans: Results from a 10-year population-based longitudinal study. Drug And Alcohol Dependence 2023, 246: 109833. PMID: 36963160, PMCID: PMC10811960, DOI: 10.1016/j.drugalcdep.2023.109833.Peer-Reviewed Original ResearchConceptsAlcohol consumption groupCurrent mental health treatmentDysphoric arousal symptomsMental health treatmentUS veteransAlcohol consumptionHealth treatmentConsumption groupArousal symptomsYounger agePopulation-based longitudinal studyPublic health problemLongitudinal studyExcessive alcohol consumptionAlcohol use disorderPosttraumatic stress disorderU.S. military veteransMedical comorbiditiesChronic courseNational HealthClose monitoringUse disordersHealth problemsVeterans StudyStress disorder
2022
Posttraumatic Stress Disorder in US Military Veterans: Results From the 2019-2020 National Health and Resilience in Veterans Study.
Wisco BE, Nomamiukor FO, Marx BP, Krystal JH, Southwick SM, Pietrzak RH. Posttraumatic Stress Disorder in US Military Veterans: Results From the 2019-2020 National Health and Resilience in Veterans Study. The Journal Of Clinical Psychiatry 2022, 83 PMID: 35192748, DOI: 10.4088/jcp.20m14029.Peer-Reviewed Original ResearchConceptsUS military veteransPosttraumatic stress disorderLifetime posttraumatic stress disorderFunctional impairmentMilitary veteran populationNational HealthMilitary veteransVeteran populationVeterans StudyTrauma exposureStress disorderGreater functional impairmentPTSD Criterion ALife Events Checklist-5Odds of lifetimeWeighted prevalencePTSD prevalenceIndirect trauma exposurePTSD ChecklistPrevalenceImpairmentPsychiatric variablesVeteransContemporary dataCriterion A
2021
Prevalence and Trends in Suicidal Behavior Among US Military Veterans During the COVID-19 Pandemic
Nichter B, Hill ML, Na PJ, Kline AC, Norman SB, Krystal JH, Southwick SM, Pietrzak RH. Prevalence and Trends in Suicidal Behavior Among US Military Veterans During the COVID-19 Pandemic. JAMA Psychiatry 2021, 78: 1218-1227. PMID: 34431973, PMCID: PMC8387942, DOI: 10.1001/jamapsychiatry.2021.2332.Peer-Reviewed Original ResearchConceptsUS military veteransCOVID-19 infectionCohort studySuicidal behaviorPast-year suicide ideationRisk factorsMilitary veteransPopulation-based prospective cohort studyCOVID-19 pandemicSuicide ideationSuicide attemptsProspective cohort studyLifetime posttraumatic stress disorderStrong risk factorCOVID-19 public health emergencyLow social supportPosttraumatic stress disorderPublic health emergencyAlcohol use disorder severityUS veteransNational HealthMAIN OUTCOMESuicide attempt historyVeterans StudyCOVID-19-related variablesMental health impact of the COVID-19 pandemic in U.S. military veterans: a population-based, prospective cohort study
Hill ML, Nichter B, Na PJ, Norman SB, Morland LA, Krystal JH, Pietrzak RH. Mental health impact of the COVID-19 pandemic in U.S. military veterans: a population-based, prospective cohort study. Psychological Medicine 2021, 53: 945-956. PMID: 34120667, PMCID: PMC8245339, DOI: 10.1017/s0033291721002361.Peer-Reviewed Original ResearchConceptsPositive screenPsychiatric distressU.S. military veteran populationMiddle-aged veteransProspective cohort studyProspective cohort surveyMajor depressive disorderMilitary veteran populationMental health problemsMental health impactU.S. military veteransCohort studyDepressive disorderNational HealthPsychiatric symptomsVeteran populationCohort surveyHealth problemsU.S. veteransVeterans StudyClinical implicationsCoronavirus diseaseProtective factorsMeaningful preMental health
2020
The National Health and Resilience in Veterans Study: A Narrative Review and Future Directions
Fogle BM, Tsai J, Mota N, Harpaz-Rotem I, Krystal JH, Southwick SM, Pietrzak RH. The National Health and Resilience in Veterans Study: A Narrative Review and Future Directions. Frontiers In Psychiatry 2020, 11: 538218. PMID: 33362593, PMCID: PMC7755975, DOI: 10.3389/fpsyt.2020.538218.Peer-Reviewed Original ResearchNational HealthVeterans StudyMental disordersNarrative reviewVeterans Affairs Healthcare SystemPopulation-based dataUnique health needsUnited States veteransPost-traumatic stress disorderNon-veteran counterpartsPost-traumatic growthProtective psychosocial characteristicsProspective studyStates veteransIndependent cohortHealth outcomesHealth needsU.S. veteransCare deliveryClinical implicationsLongitudinal changesPsychosocial characteristicsProtective factorsStress disorderTreatment efforts
2019
Posttraumatic stress symptom courses in U.S. military veterans: A seven-year, nationally representative, prospective cohort study
Mota NP, Cook JM, Smith NB, Tsai J, Harpaz-Rotem I, Krystal JH, Southwick SM, Pietrzak RH. Posttraumatic stress symptom courses in U.S. military veterans: A seven-year, nationally representative, prospective cohort study. Journal Of Psychiatric Research 2019, 119: 23-31. PMID: 31546045, DOI: 10.1016/j.jpsychires.2019.09.005.Peer-Reviewed Original ResearchConceptsPTSD symptom courseSymptom courseU.S. military veteransLatent growth mixture modelingProspective cohort studyMilitary veteransLifetime psychiatric historyMental health treatmentPhysical health difficultiesLifetime traumatic eventsTrauma-exposed veteransProtective psychosocial characteristicsCohort studyProspective cohortModerate symptomsModifiable correlatesNational HealthSymptomatic coursePsychiatric historyHealth treatmentU.S. veteransVeterans StudyPsychosocial characteristicsHigher symptomsHealth difficultiesApolipoprotein E gene polymorphism, posttraumatic stress disorder, and cognitive function in older U.S. veterans: Results from the National Health and Resilience in Veterans Study
Averill LA, Abdallah CG, Levey DF, Han S, Harpaz‐Rotem I, Kranzler HR, Southwick SM, Krystal JH, Gelernter J, Pietrzak RH. Apolipoprotein E gene polymorphism, posttraumatic stress disorder, and cognitive function in older U.S. veterans: Results from the National Health and Resilience in Veterans Study. Depression And Anxiety 2019, 36: 834-845. PMID: 31385647, DOI: 10.1002/da.22912.Peer-Reviewed Original ResearchConceptsPosttraumatic stress disorderExecutive functionCognitive functioningStress disorderΕ4 carrier statusΕ4 carriersVeterans StudyCognitive dysfunctionAttention/concentrationGreater cognitive difficultiesLower cognitive functioningOlder U.S. veteransΕ4 allele carrier statusPerseverative errorsCognitive difficultiesReplication sampleCarrier statusCognitive functionImportance of assessingNational HealthCognitive declinePredictive effectApolipoprotein E gene polymorphismE gene polymorphismΕ4 allele carriersAccelerated DNA Methylation Aging in U.S. Military Veterans: Results From the National Health and Resilience in Veterans Study
Tamman AJF, Montalvo-Ortiz JL, Southwick SM, Krystal JH, Levy BR, Pietrzak RH. Accelerated DNA Methylation Aging in U.S. Military Veterans: Results From the National Health and Resilience in Veterans Study. American Journal Of Geriatric Psychiatry 2019, 27: 528-532. PMID: 30792041, DOI: 10.1016/j.jagp.2019.01.001.Peer-Reviewed Original ResearchConceptsNational HealthPsychosocial factorsVeterans StudyMale U.S. veteransLifetime trauma burdenAccelerated DNA methylation agingDNA methylation agingU.S. military veteransMethylation agingTrauma burdenU.S. veteransPrevention effortsAdditional correlatesNegative beliefsMilitary veteransSexual traumaVeteransTraumatic stressDNA methylationHealthChild sexual traumaBody massRepresentative sample
2018
Trajectories of alcohol consumption in U.S. military veterans: Results from the National Health and Resilience in Veterans Study
Fuehrlein BS, Kachadourian LK, DeVylder EK, Trevisan LA, Potenza MN, Krystal JH, Southwick SM, Pietrzak RH. Trajectories of alcohol consumption in U.S. military veterans: Results from the National Health and Resilience in Veterans Study. American Journal On Addictions 2018, 27: 383-390. PMID: 29667712, DOI: 10.1111/ajad.12731.Peer-Reviewed Original ResearchMajor depressive disorderLifetime major depressive disorderAlcohol consumptionPredominant trajectoriesNational HealthVeterans StudyAlcohol Use Disorders Identification Test-ConsumptionBrief alcohol screensExcessive drinkingPopulation-based preventionSocial supportExcessive alcohol consumptionAlcohol use disorderLow social supportU.S. military veteransAlcohol screenBaseline determinantsDepressive disorderLatent growth mixture modelingMedical conditionsModerate drinkersRare drinkersModerate drinkingUse disordersGreater social support
2017
Apolipoprotein E gene polymorphism, trauma burden, and posttraumatic stress symptoms in U.S. military veterans: Results from the National Health and Resilience in Veterans Study
Mota NP, Han S, Harpaz‐Rotem I, Maruff P, Krystal JH, Southwick SM, Gelernter J, Pietrzak RH. Apolipoprotein E gene polymorphism, trauma burden, and posttraumatic stress symptoms in U.S. military veterans: Results from the National Health and Resilience in Veterans Study. Depression And Anxiety 2017, 35: 168-177. PMID: 29172227, PMCID: PMC5794529, DOI: 10.1002/da.22698.Peer-Reviewed Original ResearchConceptsΕ4 allele carriersApolipoprotein E gene polymorphismE gene polymorphismTrauma burdenU.S. military veteransAllele carriersPosttraumatic stress disorderPTSD symptomsNational HealthGreater social supportGene polymorphismsGreater severityMilitary veteransVeterans StudyAPOE ε4 carrier statusSocial supportΕ4 carrier statusAPOE genotypeΕ4 noncarriersPosttraumatic stress symptomsIndependent replication sampleSymptomsPTSD riskStress disorderCarrier statusPolygenic Scores for Major Depressive Disorder and Risk of Alcohol Dependence
Andersen AM, Pietrzak RH, Kranzler HR, Ma L, Zhou H, Liu X, Kramer J, Kuperman S, Edenberg HJ, Nurnberger JI, Rice JP, Tischfield JA, Goate A, Foroud TM, Meyers JL, Porjesz B, Dick DM, Hesselbrock V, Boerwinkle E, Southwick SM, Krystal JH, Weissman MM, Levinson DF, Potash JB, Gelernter J, Han S. Polygenic Scores for Major Depressive Disorder and Risk of Alcohol Dependence. JAMA Psychiatry 2017, 74: 1153-1160. PMID: 28813562, PMCID: PMC5710224, DOI: 10.1001/jamapsychiatry.2017.2269.Peer-Reviewed Original ResearchConceptsMDD polygenic risk scoresMajor depressive disorderPolygenic risk scoresAlcohol dependenceDepressive disorderSignificant public health burdenPublic health burdenAD comorbidityNational HealthHealth burdenMAIN OUTCOMECase-control statusRisk scoreRisk of ADVeterans StudyYale-PennGenetic susceptibilityMDD statusCommon genetic factorsSubstance dependenceMDD casesAD samplesPolygenic riskGenetic factorsHeritable disorderMoral injury in U.S. combat veterans: Results from the national health and resilience in veterans study
Wisco BE, Marx BP, May CL, Martini B, Krystal JH, Southwick SM, Pietrzak RH. Moral injury in U.S. combat veterans: Results from the national health and resilience in veterans study. Depression And Anxiety 2017, 34: 340-347. PMID: 28370818, DOI: 10.1002/da.22614.Peer-Reviewed Original ResearchMental disordersNational HealthCombat veteransU.S. combat veteransCurrent mental disorderPast psychiatric disordersPopulation-based sampleCombat severityMental health problemsMoral Injury Events ScaleFunctional outcomeMoral injuryWhite racePsychiatric disordersHealth problemsU.S. veteransSuicidal ideationVeterans StudySuicide attemptsInjurious eventsCombat exposureSociodemographic variablesDisordersExposure historyVeterans
2016
Hostility and telomere shortening among U.S. military veterans: Results from the National Health and Resilience in Veterans Study
Watkins LE, Harpaz-Rotem I, Sippel LM, Krystal JH, Southwick SM, Pietrzak RH. Hostility and telomere shortening among U.S. military veterans: Results from the National Health and Resilience in Veterans Study. Psychoneuroendocrinology 2016, 74: 251-257. PMID: 27689898, DOI: 10.1016/j.psyneuen.2016.09.006.Peer-Reviewed Original ResearchConceptsU.S. military veteransClinical variablesNational HealthTelomere lengthMilitary veteransMultivariable binary logistic regression analysisVeterans StudyAccelerated cellular agingBinary logistic regression analysisLogistic regression analysisU.S. veteran populationNon-veteran populationsAge-related disordersPolymerase chain reaction methodChronic disordersRisk factorsChain reaction methodQuantitative polymerase chain reaction methodVeteran populationU.S. veteransSecondary analysisTreatment effortsVeteransRegression analysisBiological ageProbable Posttraumatic Stress Disorder in the US Veteran Population According to DSM-5: Results From the National Health and Resilience in Veterans Study.
Wisco BE, Marx BP, Miller MW, Wolf EJ, Mota NP, Krystal JH, Southwick SM, Pietrzak RH. Probable Posttraumatic Stress Disorder in the US Veteran Population According to DSM-5: Results From the National Health and Resilience in Veterans Study. The Journal Of Clinical Psychiatry 2016, 77: 1503-1510. PMID: 27631148, DOI: 10.4088/jcp.15m10188.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAfghan Campaign 2001-AgedCohort StudiesCombat DisordersComorbidityCross-Sectional StudiesDiagnostic and Statistical Manual of Mental DisordersFemaleFollow-Up StudiesHealth SurveysHumansIraq War, 2003-2011Life Change EventsMaleMental DisordersMiddle AgedResilience, PsychologicalStress Disorders, Post-TraumaticSurveys and QuestionnairesVeteransYoung AdultConceptsProbable posttraumatic stress disorderDSM-5 posttraumatic stress disorderPosttraumatic stress disorderUS veteran populationPsychiatric comorbidityUS veteransNational HealthVeteran populationVeterans StudyStress disorderPTSD symptomsOdds of moodHigh public health burdenPublic health burdenPopulation-based samplePast-month prevalenceDSM-5Specific PTSD symptomsHigh rateWeighted lifetimeNew symptomsHealth burdenLow prevalencePsychiatric disordersPTSD Checklist-5The burden of hostility in U.S. Veterans: Results from the National Health and Resilience in Veterans Study
Sippel LM, Mota NP, Kachadourian LK, Krystal JH, Southwick SM, Harpaz-Rotem I, Pietrzak RH. The burden of hostility in U.S. Veterans: Results from the National Health and Resilience in Veterans Study. Psychiatry Research 2016, 243: 421-430. PMID: 27450745, DOI: 10.1016/j.psychres.2016.06.040.Peer-Reviewed Original ResearchConceptsS. veteransLongitudinal courseNational HealthProtective correlatesVeterans StudyProspective cohort studyPopulation-based evaluationPopulation-based dataAggressive urgesMajority of veteransPhysical health consequencesProtective psychosocial characteristicsCohort studySymptomatic courseAlcohol misuseU.S. veteransPsychosocial characteristicsHealth consequencesTreatment effortsPsychological distressVeteransTwo-year periodPrevalenceRiskSocial connectednessThe burden of alcohol use disorders in US military veterans: results from the National Health and Resilience in Veterans Study
Fuehrlein BS, Mota N, Arias AJ, Trevisan LA, Kachadourian LK, Krystal JH, Southwick SM, Pietrzak RH. The burden of alcohol use disorders in US military veterans: results from the National Health and Resilience in Veterans Study. Addiction 2016, 111: 1786-1794. PMID: 27061707, DOI: 10.1111/add.13423.Peer-Reviewed Original ResearchConceptsProbable alcohol use disorderAlcohol use disorderUS military veteransAlcohol Use Disorders Identification Test-ConsumptionUse disordersLife-time historyMale sexPsychiatric comorbidityUS veteransNational HealthMilitary veteransSuicidal ideationVeterans StudyYounger ageMini International Neuropsychiatric InterviewPast-year alcohol use disorderCommon psychiatric comorbiditiesLower annual household incomeDSM-IV diagnostic criteriaLife-time diagnosisDrug use disordersInternational Neuropsychiatric InterviewMajor depressive disorderRisk of AUDLife-time suicide attemptsLate-life exacerbation of PTSD symptoms in US veterans: results from the National Health and Resilience in Veterans Study.
Mota N, Tsai J, Kirwin PD, Harpaz-Rotem I, Krystal JH, Southwick SM, Pietrzak RH. Late-life exacerbation of PTSD symptoms in US veterans: results from the National Health and Resilience in Veterans Study. The Journal Of Clinical Psychiatry 2016, 77: 348-54. PMID: 27046308, DOI: 10.4088/jcp.15m10101.Peer-Reviewed Original ResearchConceptsOlder US veteransPosttraumatic stress disorderUS veteransPTSD symptomsNational HealthVeterans StudyMultivariable logistic regression modelWorst traumaDelayed-onset posttraumatic stress disorderExecutive dysfunctionWave 2Population-based dataUS military veteransLogistic regression modelsWave 1Cohort studySignificant exacerbationGreater severitySymptomsOlder ageStress disorderSelf-reported cognitive difficultiesPotential targetMilitary veteransLater life
2014
Dimensional structure of DSM-5 posttraumatic stress disorder symptoms: results from the National Health and Resilience in Veterans Study.
Tsai J, Harpaz-Rotem I, Armour C, Southwick SM, Krystal JH, Pietrzak RH. Dimensional structure of DSM-5 posttraumatic stress disorder symptoms: results from the National Health and Resilience in Veterans Study. The Journal Of Clinical Psychiatry 2014, 76: 546-53. PMID: 25562376, DOI: 10.4088/jcp.14m09091.Peer-Reviewed Original ResearchConceptsPosttraumatic stress disorderLifetime posttraumatic stress disorderHealth-related functioningMental health-related functioningDSM-5 posttraumatic stress disorderUS veteransSymptom clustersPTSD symptom clustersNational HealthVeterans StudyPTSD symptomsQuality of lifeDysphoric Arousal modelPosttraumatic stress disorder (PTSD) symptomsDSM-5 posttraumatic stress disorder symptomsDSM-5 PTSD symptom clustersHealth outcomesFemale veteransSuicidal ideationDSM-5 PTSD symptomsStress disorderSymptomsDisorder symptomsPTSD symptomatologyVeterans