2023
A computational model for learning from repeated traumatic experiences under uncertainty
Kaye A, Rao M, Kwan A, Ressler K, Krystal J. A computational model for learning from repeated traumatic experiences under uncertainty. Cognitive, Affective, & Behavioral Neuroscience 2023, 23: 894-904. PMID: 37165181, PMCID: PMC11149767, DOI: 10.3758/s13415-023-01085-5.Peer-Reviewed Original ResearchPosttraumatic stress disorderTraumatic eventsNovel contextThreat perceptionTreatment of PTSDEarly life traumaNeutral cuesThreat responsesStress disorderLife traumaTraumatic experiencesPrediction errorComputational theorySensory cuesPTSD incidenceNovel predictionsUnpredictable footshockInternal statesComputational modelCuesPerceptionSpecific associationFootshockContextTheory
2017
Computational Psychiatry and the Challenge of Schizophrenia
Krystal JH, Murray JD, Chekroud AM, Corlett PR, Yang G, Wang XJ, Anticevic A. Computational Psychiatry and the Challenge of Schizophrenia. Schizophrenia Bulletin 2017, 43: 473-475. PMID: 28338845, PMCID: PMC5464204, DOI: 10.1093/schbul/sbx025.Peer-Reviewed Original ResearchConceptsComputational psychiatryReinforcement learning theoryNeural circuit modelMachine learningComplex datasetsFormal modelLarge datasetsLearning theorySchizophrenia researchDatasetSchizophreniaFormal theoryEnormous challengesPsychiatryDisordersLearningChallengesTheoryDifficultiesModelReadersApplicationsResearchPath