2008
Ethanol-like effects of thiopental and ketamine in healthy humans
Dickerson D, Pittman B, Ralevski E, Perrino A, Limoncelli D, Edgecombe J, Acampora G, Krystal J, Petrakis I. Ethanol-like effects of thiopental and ketamine in healthy humans. Journal Of Psychopharmacology 2008, 24: 203-211. PMID: 19028835, PMCID: PMC4484757, DOI: 10.1177/0269881108098612.Peer-Reviewed Original ResearchConceptsEthanol-like effectsEthanol-related effectsNMDA receptor antagonistBlock NMDA receptorsNMDA receptor antagonismSeparate test daysGamma-aminobutyric acidReceptor antagonismSubanesthetic dosesReceptor antagonistNMDA receptorsFamily historyEthanol intoxicationHealthy humansPharmacological agentsEthanol effectsKetamineReceptor activityReceptor functionLarger studyBehavioral effectsThiopentalIntoxicationSubjective intoxicationTest day
2002
The Effect of Tryptophan Depletion on Alcohol Self‐Administration in Non‐Treatment‐Seeking Alcoholic Individuals
Petrakis IL, Buonopane A, O'Malley S, Cermik O, Trevisan L, Boutros NN, Limoncelli D, Krystal JH. The Effect of Tryptophan Depletion on Alcohol Self‐Administration in Non‐Treatment‐Seeking Alcoholic Individuals. Alcohol Clinical And Experimental Research 2002, 26: 969-975. PMID: 12170105, DOI: 10.1111/j.1530-0277.2002.tb02629.x.Peer-Reviewed Original ResearchConceptsTest sessionsActive tryptophan depletionSelf-reported cravingTryptophan depletionFavorite alcoholic beverageCue exposure sessionsAmount of alcoholAmino acid drinkSelf-administration paradigmAlcohol-dependent individualsAlcohol Self-AdministrationAlcohol use disorderDependence of alcoholNeurobiological mechanismsExposure sessionsSubjective intoxicationBlood alcohol levelsPriming drinkAlcohol useAcid drinkUse disordersAlcoholic individualsAlcohol dependenceCravingTest day