2011
Imaging human reward processing with positron emission tomography and functional magnetic resonance imaging
Urban NB, Slifstein M, Meda S, Xu X, Ayoub R, Medina O, Pearlson GD, Krystal JH, Abi-Dargham A. Imaging human reward processing with positron emission tomography and functional magnetic resonance imaging. Psychopharmacology 2011, 221: 67-77. PMID: 22052081, DOI: 10.1007/s00213-011-2543-6.Peer-Reviewed Original ResearchConceptsPositron emission tomography studyMonetary incentive delay taskDopamine releaseVentral striatumBOLD activationVoxelwise analysisFMRI BOLD activationEndogenous dopamine releaseEmission tomography studiesROI analysisMesolimbic dopamine releaseFunctional magnetic resonance imagingMagnetic resonance imagingPositron emission tomographyReward processingBOLD signal changesFunctional neuroimaging studiesPrecommissural putamenIncentive delay taskSignal changesPosterior caudateStriatal subregionsHealthy subjectsGlutamatergic signalingPercent change
2010
Individuals Family History Positive for Alcoholism Show Functional Magnetic Resonance Imaging Differences in Reward Sensitivity That Are Related to Impulsivity Factors
Andrews MM, Meda SA, Thomas AD, Potenza MN, Krystal JH, Worhunsky P, Stevens MC, O'Malley S, Book GA, Reynolds B, Pearlson GD. Individuals Family History Positive for Alcoholism Show Functional Magnetic Resonance Imaging Differences in Reward Sensitivity That Are Related to Impulsivity Factors. Biological Psychiatry 2010, 69: 675-683. PMID: 21126735, PMCID: PMC3677031, DOI: 10.1016/j.biopsych.2010.09.049.Peer-Reviewed Original ResearchConceptsMonetary incentive delay taskIncentive delay taskNAcc activationReward anticipationDelay taskFamily history-positive individualsAbnormal reward processingRegional brain activationNucleus accumbens activationFunctional magnetic resonanceReward system activitySubstance-abusing individualsReward prospectReward sensitivityNeural correlatesImpulsivity constructsSubstance abuse historyImpulsivity factorsReward processingBehavioral impulsivityAtypical activationBrain activationOutcome phaseBiological predispositionTask phases