2016
50 Hz hippocampal stimulation in refractory epilepsy: Higher level of basal glutamate predicts greater release of glutamate
Cavus I, Widi GA, Duckrow RB, Zaveri H, Kennard JT, Krystal J, Spencer DD. 50 Hz hippocampal stimulation in refractory epilepsy: Higher level of basal glutamate predicts greater release of glutamate. Epilepsia 2016, 57: 288-297. PMID: 26749134, DOI: 10.1111/epi.13269.Peer-Reviewed Original ResearchConceptsBasal glutamate levelsRefractory epilepsyGlutamate effluxBasal glutamateGlutamate levelsElectrical stimulationEpileptic hippocampusGlutamate releaseSeizure groupHz stimulationBrain glutamate releaseHippocampus of patientsStimulation-induced increaseEpilepsy monitoring unitStimulation-induced changesEpileptogenic hippocampusInduced seizuresSeizure inductionSpontaneous seizuresInterictal levelsGlutamate increaseAtrophic hippocampusElectroencephalography evaluationHippocampal stimulationHippocampal electrodes
2005
Extracellular metabolites in the cortex and hippocampus of epileptic patients
Cavus I, Kasoff WS, Cassaday MP, Jacob R, Gueorguieva R, Sherwin RS, Krystal JH, Spencer DD, Abi‐Saab W. Extracellular metabolites in the cortex and hippocampus of epileptic patients. Annals Of Neurology 2005, 57: 226-235. PMID: 15668975, DOI: 10.1002/ana.20380.Peer-Reviewed Original ResearchConceptsGlutamate-glutamine cyclingEpileptogenic hippocampusGlutamate levelsEpileptic patientsImpaired glutamate reuptakeBasal glutamate levelsBrain energy metabolismHigher lactate levelsGlutamine/glutamate ratioPoor glucose utilizationEnergy metabolismNeurometabolic processesNonepileptogenic cortexEpileptogenic cortexGlutamate reuptakeNeocortical epilepsyExtracellular glutamateSeizure generationInterictal periodLactate levelsMicrodialysis methodExtracellular levelsNeuronal toxicityGlucose utilizationDepth electrodes