2016
The Interplay Between Risky Sexual Behaviors and Alcohol Dependence: Genome-Wide Association and Neuroimaging Support for LHPP as a Risk Gene
Polimanti R, Wang Q, Meda SA, Patel KT, Pearlson GD, Zhao H, Farrer LA, Kranzler HR, Gelernter J. The Interplay Between Risky Sexual Behaviors and Alcohol Dependence: Genome-Wide Association and Neuroimaging Support for LHPP as a Risk Gene. Neuropsychopharmacology 2016, 42: 598-605. PMID: 27531626, PMCID: PMC5240175, DOI: 10.1038/npp.2016.153.Peer-Reviewed Original ResearchConceptsRisky sexual behaviorAlcohol dependenceLow-frequency fluctuation (ALFF) analysisLeft superior frontal gyrusMultiple sexual partnersDSM-IV criteriaSexual behaviorMagnetic Resonance Imaging AnalysisAnterior cingulate regionsSuperior frontal gyrusMonetary incentive delay taskLifetime alcohol dependenceIncentive delay taskRight amygdalaClinical relevanceSTD riskUnprotected sexBrain circuitryFunctional magnetic resonance imaging (fMRI) analysisCingulate regionsSexual partnersFrequency fluctuation analysisFrontal gyrusGenetic findingsReduced activation
2008
Role of Variation in the Serotonin Transporter Protein Gene (SLC6A4) in Trait Disturbances in the Ventral Anterior Cingulate in Bipolar Disorder
Shah MP, Wang F, Kalmar JH, Chepenik LG, Tie K, Pittman B, Jones MM, Constable RT, Gelernter J, Blumberg HP. Role of Variation in the Serotonin Transporter Protein Gene (SLC6A4) in Trait Disturbances in the Ventral Anterior Cingulate in Bipolar Disorder. Neuropsychopharmacology 2008, 34: 1301-1310. PMID: 19037205, PMCID: PMC2826628, DOI: 10.1038/npp.2008.204.Peer-Reviewed Original ResearchConceptsVentral anterior cingulate cortexBipolar disorderFeatures of BDS carriersAnterior cingulate cortexVentral anterior cingulateEvent-related functional magnetic resonanceFunctional magnetic resonanceTransporter promoter polymorphismSerotonergic systemBD subgroupsHealthy comparison participantsBD groupVACC activationHC groupPromoter polymorphismFuture treatmentHealthy individualsAnterior cingulateCingulate cortexNeural systemsFunctional connectivityDysfunctionSerotonin transporter protein geneAmygdala activation