2020
GABAergic polygenic risk for cocaine use disorder is negatively correlated with precuneus activity during cognitive control in African American individuals
Yang BZ, Balodis IM, Kober H, Worhunsky PD, Lacadie CM, Gelernter J, Potenza MN. GABAergic polygenic risk for cocaine use disorder is negatively correlated with precuneus activity during cognitive control in African American individuals. Addictive Behaviors 2020, 114: 106695. PMID: 33153773, PMCID: PMC8299472, DOI: 10.1016/j.addbeh.2020.106695.Peer-Reviewed Original Research
2013
Genome-wide association study of cocaine dependence and related traits: FAM53B identified as a risk gene
Gelernter J, Sherva R, Koesterer R, Almasy L, Zhao H, Kranzler HR, Farrer L. Genome-wide association study of cocaine dependence and related traits: FAM53B identified as a risk gene. Molecular Psychiatry 2013, 19: 717-723. PMID: 23958962, PMCID: PMC3865158, DOI: 10.1038/mp.2013.99.Peer-Reviewed Original ResearchMeSH KeywordsAdultBlack or African AmericanCDC2 Protein KinaseCocaineCocaine-Related DisordersCyclin-Dependent KinasesDopamine Uptake InhibitorsFemaleGenetic Predisposition to DiseaseGenome-Wide Association StudyGenotyping TechniquesHumansMaleNuclear Receptor Co-Repressor 2Paranoid DisordersPolymorphism, Single NucleotideUnited StatesWhite PeopleConceptsGenome-wide association studiesAssociation studiesAvailable GWAS dataSignificant GWAS SNPsNovel risk lociGWAS data setsSame chromosomal regionDiscovery sampleGenomes reference panelPrevious linkage studiesGWAS SNPsGWAS dataRelated traitsChromosomal regionsRisk lociRisk genesRisk variantsGenesReference panelAdditional genotypesLinkage studiesLociEuropean-American subjectsCocaine-induced paranoiaFAM53BA Complex Interplay between Personality Domains, Marital Status and a Variant in CHRNA5 on the Risks of Cocaine, Nicotine Dependences and Cocaine-Induced Paranoia
Zayats T, Yang BZ, Xie P, Poling J, Farrer LA, Gelernter J. A Complex Interplay between Personality Domains, Marital Status and a Variant in CHRNA5 on the Risks of Cocaine, Nicotine Dependences and Cocaine-Induced Paranoia. PLOS ONE 2013, 8: e49368. PMID: 23308091, PMCID: PMC3538653, DOI: 10.1371/journal.pone.0049368.Peer-Reviewed Original Research
2011
Association between polymorphisms in catechol‐O‐methyltransferase (COMT) and cocaine‐induced paranoia in European‐American and African‐American populations
Ittiwut R, Listman JB, Ittiwut C, Cubells JF, Weiss RD, Brady K, Oslin D, Farrer LA, Kranzler HR, Gelernter J. Association between polymorphisms in catechol‐O‐methyltransferase (COMT) and cocaine‐induced paranoia in European‐American and African‐American populations. American Journal Of Medical Genetics Part B Neuropsychiatric Genetics 2011, 156: 651-660. PMID: 21656904, PMCID: PMC3864552, DOI: 10.1002/ajmg.b.31205.Peer-Reviewed Original Research
2008
Interaction between Two Independent CNR1 Variants Increases Risk for Cocaine Dependence in European Americans: A Replication Study in Family-Based Sample and Population-Based Sample
Zuo L, Kranzler HR, Luo X, Yang BZ, Weiss R, Brady K, Poling J, Farrer L, Gelernter J. Interaction between Two Independent CNR1 Variants Increases Risk for Cocaine Dependence in European Americans: A Replication Study in Family-Based Sample and Population-Based Sample. Neuropsychopharmacology 2008, 34: 1504-1513. PMID: 19052543, PMCID: PMC2879626, DOI: 10.1038/npp.2008.206.Peer-Reviewed Original ResearchBlack or African AmericanCase-Control StudiesCluster AnalysisCocaineCocaine-Related DisordersFamilyGenetic Predisposition to DiseaseHaplotypesHumansLinkage DisequilibriumParanoid DisordersPolymorphism, Single NucleotideReceptor, Cannabinoid, CB1Regression AnalysisSequence Analysis, DNAUnited StatesWhite People
2007
Comorbid Psychiatric Diagnoses and Their Association with Cocaine‐Induced Psychosis in Cocaine‐Dependent Subjects
Tang Y, Kranzler HR, Gelernter J, Farrer LA, Cubells JF. Comorbid Psychiatric Diagnoses and Their Association with Cocaine‐Induced Psychosis in Cocaine‐Dependent Subjects. American Journal On Addictions 2007, 16: 343-351. PMID: 17882604, DOI: 10.1080/10550490701525723.Peer-Reviewed Original ResearchConceptsAttention deficit hyperactivity disorderCocaine-Induced PsychosisComorbid substance useAntisocial personality disorderCocaine Experience QuestionnairePsychiatric disordersUse disordersPsychiatric diagnosisCocaine dependenceAxis I psychiatric diagnosesComorbid opioid dependenceSubstance useAdult antisocial personality disorderComorbid attention deficit hyperactivity disorderPercent of subjectsComorbid psychiatric diagnosesDSM-IV diagnosisSubstance use disordersCocaine-dependent adultsCocaine-dependent subjectsCocaine-dependent sampleSemi-Structured AssessmentDrugs of abuseDeficit hyperactivity disorderSuch comorbidities
2006
Dopamine β-Hydroxylase Gene (DβH) -1021C→T Influences Self-Reported Paranoia during Cocaine Self-Administration
Kalayasiri R, Sughondhabirom A, Gueorguieva R, Coric V, Lynch WJ, Lappalainen J, Gelernter J, Cubells JF, Malison RT. Dopamine β-Hydroxylase Gene (DβH) -1021C→T Influences Self-Reported Paranoia during Cocaine Self-Administration. Biological Psychiatry 2006, 61: 1310-1313. PMID: 17157269, DOI: 10.1016/j.biopsych.2006.08.012.Peer-Reviewed Original Research
2005
Rating the severity and character of transient cocaine-induced delusions and hallucinations with a new instrument, the Scale for Assessment of Positive Symptoms for Cocaine-Induced Psychosis (SAPS-CIP)
Cubells JF, Feinn R, Pearson D, Burda J, Tang Y, Farrer LA, Gelernter J, Kranzler HR. Rating the severity and character of transient cocaine-induced delusions and hallucinations with a new instrument, the Scale for Assessment of Positive Symptoms for Cocaine-Induced Psychosis (SAPS-CIP). Drug And Alcohol Dependence 2005, 80: 23-33. PMID: 15894433, DOI: 10.1016/j.drugalcdep.2005.03.019.Peer-Reviewed Original ResearchIncreased dopamine transporter availability associated with the 9-repeat allele of the SLC6A3 gene.
van Dyck CH, Malison RT, Jacobsen LK, Seibyl JP, Staley JK, Laruelle M, Baldwin RM, Innis RB, Gelernter J. Increased dopamine transporter availability associated with the 9-repeat allele of the SLC6A3 gene. Journal Of Nuclear Medicine 2005, 46: 745-51. PMID: 15872345.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAgedAged, 80 and overAgingCocaineCorpus StriatumDopamine Plasma Membrane Transport ProteinsFemaleGene FrequencyGenetic TestingHumansMaleMembrane GlycoproteinsMembrane Transport ProteinsMicrosatellite RepeatsMiddle AgedNerve Tissue ProteinsPolymorphism, GeneticRadionuclide ImagingRadiopharmaceuticalsTissue DistributionConceptsStriatal DAT availabilityDAT availabilityDopamine transporterDAT genotypeDopamine transporter availabilityBrain uptakeTransporter availabilityHealthy European AmericansDAT levelsCarbomethoxy-3betaClinical phenotypeMean increaseNeuropsychiatric diseasesSLC6A3 polymorphismsVNTR polymorphismSLC6A3European AmericansSLC6A3 geneHomozygotesHuman clinical phenotypesSubregion analysisPolymorphismDivergent resultsAssociationCommon alleles
2004
Central Serotonin Transporter Availability Measured With 123I-CIT SPECT in Relation to Serotonin Transporter Genotype
van Dyck CH, Malison RT, Staley JK, Jacobsen LK, Seibyl JP, Laruelle M, Baldwin RM, Innis RB, Gelernter J. Central Serotonin Transporter Availability Measured With 123I-CIT SPECT in Relation to Serotonin Transporter Genotype. American Journal Of Psychiatry 2004, 161: 525-531. PMID: 14992979, DOI: 10.1176/appi.ajp.161.3.525.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAgedAged, 80 and overAllelesBrainBrain MappingCarrier ProteinsCocaineFemaleGene FrequencyGenotypeHumansIodine RadioisotopesMaleMembrane GlycoproteinsMembrane Transport ProteinsMiddle AgedNerve Tissue ProteinsPolymorphism, GeneticPromoter Regions, GeneticReference ValuesSerotonin Plasma Membrane Transport ProteinsTandem Repeat SequencesTomography, Emission-Computed, Single-PhotonConceptsSERT availabilitySerotonin transporter proteinEuropean-American subjectsSERT levelsCentral serotonin transporter availabilitySLC6A4 promoter polymorphismSerotonin transporter availabilitySingle photon emissionEffect of ageLong alleleSerotonin transmissionBrain uptakeLong homozygotesAmerican subjectsTransporter availabilityPromoter polymorphismSerotonin transporter genotypeClinical phenotypeTomography scanningNeuropsychiatric diseasesNonneural cellsFunctional polymorphismsSLC6A4 genotypeNonsignificant tendencyTransporter genotype
2001
The Variable Number of Tandem Repeats Polymorphism of the Dopamine Transporter Gene Is Not Associated with Significant Change in Dopamine Transporter Phenotype in Humans
Martinez D, Gelernter J, Abi-Dargham A, van Dyck C, Kegeles L, Innis R, Laruelle M. The Variable Number of Tandem Repeats Polymorphism of the Dopamine Transporter Gene Is Not Associated with Significant Change in Dopamine Transporter Phenotype in Humans. Neuropsychopharmacology 2001, 24: 553-560. PMID: 11282255, DOI: 10.1016/s0893-133x(00)00216-5.Peer-Reviewed Original ResearchMeSH KeywordsAdultAmphetamineAttention Deficit Disorder with HyperactivityBenzamidesCarrier ProteinsCocaineCocaine-Related DisordersDopamineDopamine AntagonistsDopamine Plasma Membrane Transport ProteinsGenotypeHumansIodine RadioisotopesMembrane GlycoproteinsMembrane Transport ProteinsMinisatellite RepeatsNeostriatumNerve Tissue ProteinsPhenotypePolymorphism, GeneticPsychotic DisordersPyrrolidinesRadiopharmaceuticalsSchizophreniaTomography, Emission-Computed, Single-PhotonConceptsAmphetamine-induced dopamine releaseDopamine releaseDAT expressionDopamine transporterDifferent patient populationsAttention deficit hyperactivity disorderDeficit hyperactivity disorderNeurochemical phenotypePatient populationHealthy controlsDAT densityComputerized emission tomographyDopamine transmissionClinical phenotypeDiagnostic groupsSignificant associationEmission tomographyCocaine-induced paranoiaHyperactivity disorderTandem repeat polymorphismVNTR polymorphismDopamine transporter geneRepeat polymorphismTotal sample
1994
Genetic Association between Dopamine Transporter Protein Alleles and Cocaine-Induced Paranoia
Gelernter J, Kranzler H, Satel S, Rao P. Genetic Association between Dopamine Transporter Protein Alleles and Cocaine-Induced Paranoia. Neuropsychopharmacology 1994, 11: 195-200. PMID: 7865100, DOI: 10.1038/sj.npp.1380106.Peer-Reviewed Original Research