2014
Clinical features of methamphetamine‐induced paranoia and preliminary genetic association with DBH‐1021C→T in a Thai treatment cohort
Kalayasiri R, Verachai V, Gelernter J, Mutirangura A, Malison RT. Clinical features of methamphetamine‐induced paranoia and preliminary genetic association with DBH‐1021C→T in a Thai treatment cohort. Addiction 2014, 109: 965-976. PMID: 24521142, PMCID: PMC4018411, DOI: 10.1111/add.12512.Peer-Reviewed Original ResearchConceptsDopamine β-hydroxylaseMethamphetamine-dependent individualsAssociated clinical variablesGenetic polymorphismsΒ-hydroxylaseLogistic regression analysisSubstance abuse treatment centersHigh-activity genotypesSemi-Structured AssessmentAntisocial personality disorderCT carriersCent of individualsClinical featuresClinical presentationCigarette smokingClinical variablesRetrospective analysisTreatment centersDrug dependenceActivity genotypeMethamphetamine useMethamphetamine dependencePersonality disorderRegression analysisGenetic association
2001
Human GABAB receptor 1 gene: Eight novel sequence variants
Hisama F, Gruen J, Choi J, Huseinovic M, Grigorenko E, Pauls D, Mattson R, Gelernter J, Wood F, Goei V. Human GABAB receptor 1 gene: Eight novel sequence variants. Human Mutation 2001, 17: 349-350. PMID: 11295833, DOI: 10.1002/humu.34.Peer-Reviewed Original ResearchMeSH KeywordsChromosome MappingChromosomes, Human, Pair 6DNA Mutational AnalysisDNA PrimersExonsGene FrequencyGenetic Predisposition to DiseaseGenetic VariationHumansIntronsMental DisordersMutationMutation, MissensePolymorphism, GeneticPolymorphism, Restriction Fragment LengthPolymorphism, Single-Stranded ConformationalReceptors, GABA-BUnited StatesConceptsNeurobehavioral disordersPrincipal inhibitory neurotransmitterHuman leukocyte antigen (HLA) regionInhibitory neurotransmitterPharmacogenetic studiesGene mutationsAntigen regionIntron variantsMissense mutationsDistinct mutationsDisordersLinkage studiesReceptor mapsAmerican populationGABBR1MutationsSusceptibility regionsEpilepsyCandidate genesDNA variantsGABANeurotransmittersSchizophreniaBrainA Quantitative-Trait Analysis of Human Plasma–Dopamine β-Hydroxylase Activity: Evidence for a Major Functional Polymorphism at the DBH Locus
Zabetian C, Anderson G, Buxbaum S, Elston R, Ichinose H, Nagatsu T, Kim K, Kim C, Malison R, Gelernter J, Cubells J. A Quantitative-Trait Analysis of Human Plasma–Dopamine β-Hydroxylase Activity: Evidence for a Major Functional Polymorphism at the DBH Locus. American Journal Of Human Genetics 2001, 68: 515-522. PMID: 11170900, PMCID: PMC1235285, DOI: 10.1086/318198.Peer-Reviewed Original ResearchConceptsQuantitative trait lociMajor quantitative trait locusMajor genetic markerH activityQuantitative trait analysisStructural geneGenotype/phenotype correlationMutational analysisExtreme phenotypesGenetic markersDBH geneHuman diseasesGenesDBH locusNovel polymorphismsCodominant inheritancePhenotype correlationUnidentified polymorphismsLociPlasma dopamine β-hydroxylase activityΒ-hydroxylase activityPolymorphismFunctional polymorphismsBeta HMajor functional polymorphisms
1999
No association between D2 dopamine receptor (DRD2) alleles or haplotypes and cocaine dependence or severity of cocaine dependence in European- and African-Americans
Gelernter J, Kranzler H, Satel S. No association between D2 dopamine receptor (DRD2) alleles or haplotypes and cocaine dependence or severity of cocaine dependence in European- and African-Americans. Biological Psychiatry 1999, 45: 340-345. PMID: 10023512, DOI: 10.1016/s0006-3223(97)00537-4.Peer-Reviewed Original ResearchAllelesBehavior, AddictiveBlack PeopleCase-Control StudiesChi-Square DistributionCocaine-Related DisordersComputer SimulationFemaleGene DosageGenetic MarkersGenetic Predisposition to DiseaseHaplotypesHumansLinkage DisequilibriumMalePolymorphism, Restriction Fragment LengthReceptors, Dopamine D2Severity of Illness IndexWhite People
1997
Population genetics of a functional variant of the dopamine β‐hydroxylase gene (DBH)
Cubells J, Kobayashi K, Nagatsu T, Kidd K, Kidd J, Calafell F, Kranzler H, Ichinose H, Gelernter J. Population genetics of a functional variant of the dopamine β‐hydroxylase gene (DBH). American Journal Of Medical Genetics 1997, 74: 374-379. PMID: 9259372, DOI: 10.1002/(sici)1096-8628(19970725)74:4<374::aid-ajmg7>3.0.co;2-p.Peer-Reviewed Original Research
1995
Assignment of the 5HT7 receptor gene (HTR7) to chromosome 10q and exclusion of genetic linkage with tourette syndrome
Gelernter J, Rao P, Pauls D, Hamblin M, Sibley D, Kidd K. Assignment of the 5HT7 receptor gene (HTR7) to chromosome 10q and exclusion of genetic linkage with tourette syndrome. Genomics 1995, 26: 207-209. PMID: 7601444, DOI: 10.1016/0888-7543(95)80202-w.Peer-Reviewed Original ResearchMeSH KeywordsBlotting, SouthernChromosome MappingChromosomes, Human, Pair 10GenesHumansLod ScorePolymorphism, Restriction Fragment LengthReceptors, SerotoninTourette SyndromeConceptsGenetic linkageSomatic cell hybridsInteresting candidate genesPairwise linkage analysisCell hybridsNovel serotonin receptorCandidate genesChromosome 10Linkage analysisSouthern blotGenesExtended pedigreesLOD scoreReceptor geneLociGenetic polymorphismsHTR7PolymorphismReceptorsLIPED computer programDNALinkageHybridizationNeuropsychiatric disordersPedigree
1994
Pstl RFLP at the SERT locus
Gelernter J, Freimer M. Pstl RFLP at the SERT locus. Human Molecular Genetics 1994, 3: 383-383. PMID: 7911700, DOI: 10.1093/hmg/3.2.383.Peer-Reviewed Original ResearchBase SequenceCarrier ProteinsChromosomes, Human, Pair 17Deoxyribonucleases, Type II Site-SpecificDNA PrimersGenesHumansMembrane GlycoproteinsMembrane Transport ProteinsMolecular Sequence DataNerve Tissue ProteinsPolymerase Chain ReactionPolymorphism, Restriction Fragment LengthSerotonin Plasma Membrane Transport Proteins
1993
Assignment of the norepinephrine transporter protein (NET1) locusto chromosome 16
Gelernter J, Kruger S, Pakstis A, Pacholczyk T, Sparkes R, Kidd K, Amara S. Assignment of the norepinephrine transporter protein (NET1) locusto chromosome 16. Genomics 1993, 18: 690-692. PMID: 7905857, DOI: 10.1016/s0888-7543(05)80375-1.Peer-Reviewed Original ResearchMeSH KeywordsCarrier ProteinsChromosome MappingChromosomes, Human, Pair 16Deoxyribonucleases, Type II Site-SpecificDNA, ComplementaryGenetic LinkageGenetic MarkersHumansNorepinephrineNorepinephrine Plasma Membrane Transport ProteinsPolymorphism, Restriction Fragment LengthRestriction MappingSymportersConceptsNorepinephrine transporter proteinSomatic cell hybrid panelCell hybrid panelHybrid panelHP locusCEPH familiesLarge multigenerational familyTransporter proteinsLinkage analysisChromosome 16Provisional assignmentLinkage dataLociMultigenerational familiesGenetic polymorphismsSite of actionPreliminary assignmentNet1FamilyProteinRFLPSitesPolymorphismPCRLocalizationTaql RFLP at norepinephrine transporter protein (NET) locus
Gelernter J, Kruger S, Kidd KK, Amara S. Taql RFLP at norepinephrine transporter protein (NET) locus. Human Molecular Genetics 1993, 2: 820-820. PMID: 8102573, DOI: 10.1093/hmg/2.6.820-a.Peer-Reviewed Original ResearchThe A1 allele at the D2 dopamine receptor gene and alcoholism. A reappraisal.
Gelernter J, Goldman D, Risch N. The A1 allele at the D2 dopamine receptor gene and alcoholism. A reappraisal. JAMA 1993, 269: 1673-7. PMID: 8095994, DOI: 10.1001/jama.269.13.1673.Peer-Reviewed Original Research
1992
The D4 dopamine receptor (DRD4) maps to distal 11p close to HRAS
Gelernter J, Kennedy JL, van Tol H, Civelli O, Kidd KK. The D4 dopamine receptor (DRD4) maps to distal 11p close to HRAS. Genomics 1992, 13: 208-210. PMID: 1349574, DOI: 10.1016/0888-7543(92)90222-e.Peer-Reviewed Original ResearchMeSH KeywordsChromosome MappingChromosomes, Human, Pair 11FemaleGenes, rasGenetic LinkageHumansLod ScoreMalePolymorphism, Restriction Fragment LengthReceptors, DopamineReceptors, Dopamine D2Receptors, Dopamine D4Tyrosine 3-MonooxygenaseLinkage map of eight human chromosome 11q markers, including DRD2, spanning 60 cM
Gelernter J, Pakstis AJ, Grandy D, Litt M, Retief AE, Kennedy JL, Hing-Loh A, Schoolfield G, Civelli O, Kidd KK. Linkage map of eight human chromosome 11q markers, including DRD2, spanning 60 cM. Cytogenetic And Genome Research 1992, 60: 26-28. PMID: 1349858, DOI: 10.1159/000133287.Peer-Reviewed Original ResearchMeSH KeywordsChromosome MappingChromosomes, Human, Pair 11FemaleGenetic LinkageGenetic MarkersHumansMalePolymorphism, Restriction Fragment LengthReceptors, DopamineReceptors, Dopamine D2Sex Characteristics
1991
Sequence tagged site (STS) Taql RFLP at dopamine β-hydroxylase (DBH)
Gelernter J, Gejman PV, Bisighini S, Kidd KK. Sequence tagged site (STS) Taql RFLP at dopamine β-hydroxylase (DBH). Nucleic Acids Research 1991, 19: 1957-1957. PMID: 1674371, PMCID: PMC328142, DOI: 10.1093/nar/19.8.1957.Peer-Reviewed Original Research
1990
Manic depressive illness not linked to factor IX region in an independent series of pedigrees
Gejman P, Detera-Wadleigh S, Martinez M, Berrettini W, Goldin L, Gelernter J, Hsieh W, Gershon E. Manic depressive illness not linked to factor IX region in an independent series of pedigrees. Genomics 1990, 8: 648-655. PMID: 1980485, DOI: 10.1016/0888-7543(90)90251-o.Peer-Reviewed Original ResearchMeSH KeywordsBipolar DisorderFactor IXFemaleGenetic LinkageHumansLod ScoreMalePedigreePhenotypePolymorphism, Restriction Fragment LengthX ChromosomeGilles de la Tourette Syndrome Is Not Linked to D2-Dopamine Receptor
Gelernter J, Pakstis AJ, Pauls DL, Kurlan R, Gancher ST, Civelli O, Grandy D, Kidd KK. Gilles de la Tourette Syndrome Is Not Linked to D2-Dopamine Receptor. JAMA Psychiatry 1990, 47: 1073-1077. PMID: 1978653, DOI: 10.1001/archpsyc.1990.01810230089014.Peer-Reviewed Original ResearchChromosome MappingChromosomes, Human, Pair 11Genetic LinkageGenetic MarkersHumansLod ScoreMutationPedigreePolymorphism, Restriction Fragment LengthReceptors, DopamineTourette SyndromeHuman dopamine D1 receptor encoded by an intronless gene on chromosome 5
Sunahara R, Niznik H, Weiner D, Stormann T, Brann M, Kennedy J, Gelernter J, Rozmahel R, Yang Y, Israel Y, Seeman P, O'Dowd B. Human dopamine D1 receptor encoded by an intronless gene on chromosome 5. Nature 1990, 347: 80-83. PMID: 1975640, DOI: 10.1038/347080a0.Peer-Reviewed Original ResearchMeSH KeywordsAmino Acid SequenceAnimalsBase SequenceBenzazepinesBrain ChemistryCattleChromosomes, Human, Pair 5Cloning, MolecularGlycosylationHumansIntronsMaleMolecular Sequence DataNucleic Acid HybridizationPhosphorylationPolymorphism, Restriction Fragment LengthRatsRats, Inbred StrainsReceptors, DopamineReceptors, Dopamine D1Restriction MappingRNA, MessengerTissue DistributionTransfectionConceptsD1 receptorsD2 receptorsChromosome 5Adenylyl cyclaseCyclic AMP-dependent proteinHuman dopamine D1 receptorDopamine D1 receptorsHuman D1 receptorD1 receptor geneFamily of receptorsDrug therapyDopamine D1Dopamine D2Intronless genesParkinson's diseasePsychomotor disordersRestriction fragment length polymorphismFragment length polymorphismReceptorsFunctional typesReceptor familyDrug addictionReceptor geneAmino acidsLong arm
1988
The effects of field inversion electrophoresis on small DNA fragment mobility and its relevance to DNA polymorphism research.
Gejman PV, Sitaram N, Hsieh WT, Gelernter J, Gershon ES. The effects of field inversion electrophoresis on small DNA fragment mobility and its relevance to DNA polymorphism research. Applied And Theoretical Electrophoresis 1988, 1: 29-34. PMID: 2908735.Peer-Reviewed Original ResearchMeSH KeywordsBlotting, SouthernElectrophoresis, Agar GelImage Interpretation, Computer-AssistedPolymorphism, Restriction Fragment Length