2022
POLYGENIC RISK SCORE FOR THE PREDICTION OF ALCOHOL USE DISORDER COMORBIDITIES IN THE NATIONAL HEALTH AND RESILIENCE IN VETERANS STUDY COHORT
Mendoza B, De Lillo A, Gelernter J, Pietrzak R, Polimanti R. POLYGENIC RISK SCORE FOR THE PREDICTION OF ALCOHOL USE DISORDER COMORBIDITIES IN THE NATIONAL HEALTH AND RESILIENCE IN VETERANS STUDY COHORT. European Neuropsychopharmacology 2022, 63: e161-e162. DOI: 10.1016/j.euroneuro.2022.07.295.Peer-Reviewed Original Research
2017
Validating Harmful Alcohol Use as a Phenotype for Genetic Discovery Using Phosphatidylethanol and a Polymorphism in ADH1B
Justice AC, McGinnis KA, Tate JP, Xu K, Becker WC, Zhao H, Gelernter J, Kranzler HR. Validating Harmful Alcohol Use as a Phenotype for Genetic Discovery Using Phosphatidylethanol and a Polymorphism in ADH1B. Alcohol Clinical And Experimental Research 2017, 41: 998-1003. PMID: 28295416, PMCID: PMC5501250, DOI: 10.1111/acer.13373.Peer-Reviewed Original ResearchConceptsHarmful alcohol useAlcohol exposureAlcohol useElectronic health record dataEHR dataAUDIT-C scoresHealth record dataLongitudinal electronic health record dataLongitudinal trajectoriesChi-square testEHR-derived phenotypesStudy cohortBlood drawCommon missense polymorphismGenetic risk variantsBlood samplingMissense polymorphismAlcohol riskQuantitative biomarkersRecord dataMedianRisk variantsOverall sampleAfrican AmericansADH1B gene