2021
Genome-wide association study of stimulant dependence
Cox J, Sherva R, Wetherill L, Foroud T, Edenberg HJ, Kranzler HR, Gelernter J, Farrer LA. Genome-wide association study of stimulant dependence. Translational Psychiatry 2021, 11: 363. PMID: 34226506, PMCID: PMC8257618, DOI: 10.1038/s41398-021-01440-5.Peer-Reviewed Original ResearchConceptsStimulant dependenceAssociation studiesVoltage-gated channel proteinsGenome-wide association studiesNicotinic acetylcholine receptor genesTop GWAS signalsUse disordersAcetylcholine receptor genesWide association studyGWAS signalsSubstance use disordersEuropean ancestry subjectsNovel genesCocaine use disorderUsers of cocaineChannel proteinsGenetic studiesSpecific genetic factorsGenetics of AlcoholismSignificant pleiotropy
2018
Genomewide Association Study of Alcohol Dependence and Related Traits in a Thai Population
Gelernter J, Zhou H, Nuñez YZ, Mutirangura A, Malison RT, Kalayasiri R. Genomewide Association Study of Alcohol Dependence and Related Traits in a Thai Population. Alcohol Clinical And Experimental Research 2018, 42: 861-868. PMID: 29460428, PMCID: PMC5916336, DOI: 10.1111/acer.13614.Peer-Reviewed Original ResearchConceptsGenomewide association studiesAssociation studiesRisk genesAldehyde dehydrogenase 2Prior biological informationAfrican ancestry populationsRelated traitsSame geneBiological informationAlcohol dehydrogenasesSignificant pleiotropyDehydrogenase BGenesFunctional variantsPsychiatric traitsGenomewide significant associationPleiotropy analysisTraitsAncestry populationsFirst genomewide association studyPleiotropyDehydrogenase 2Null variants