2006
γ-Aminobutyric Acid Type A Receptors and Alcoholism: Intoxication, Dependence, Vulnerability, and Treatment
Krystal JH, Staley J, Mason G, Petrakis IL, Kaufman J, Harris RA, Gelernter J, Lappalainen J. γ-Aminobutyric Acid Type A Receptors and Alcoholism: Intoxication, Dependence, Vulnerability, and Treatment. JAMA Psychiatry 2006, 63: 957-968. PMID: 16952998, DOI: 10.1001/archpsyc.63.9.957.Peer-Reviewed Original ResearchConceptsBrain GABA systemsGABA systemAlcohol dependenceWithdrawal symptomsGABA functionGamma-aminobutyric acid (GABA) functionCortical GABA levelsAlcohol withdrawal symptomsΓ-Aminobutyric Acid Type A ReceptorsEnvironmental risk factorsLong-term alcohol effectsType A ReceptorsAlcohol-dependent individualsLong-term sobrietyGABA releaseNeurosteroid levelsAcute withdrawalAlcoholism vulnerabilityGABA neurotransmissionRisk factorsGABA levelsExtrasynaptic locationsLow chloride conductanceReceptor densityTonic component
1988
Schizophrenia: Instability in Norepinephrine, Serotonin, and γ-Aminobutyric Acid Systems
Gelernter J, van Kammen D. Schizophrenia: Instability in Norepinephrine, Serotonin, and γ-Aminobutyric Acid Systems. International Review Of Neurobiology 1988, 29: 309-347. PMID: 3042667, DOI: 10.1016/s0074-7742(08)60091-4.Peer-Reviewed Original ResearchConceptsGABA systemΓ-aminobutyric acid (GABA) systemPathophysiology of schizophreniaClinical instabilitySymptomatic periodClinical syndromeDA dysregulationNeurotransmitter systemsSystem disordersState-dependent changesClinical pathologyConflicting dataSchizophrenia researchSchizophreniaDopamineGenetic vulnerabilitySchizophrenic individualsMost evidenceNorepinephrineSerotoninNE systemDisordersEvidenceRelapsePathophysiology