2022
Polygenic scores for empathy associate with posttraumatic stress severity in response to certain traumatic events
Wendt FR, Warrier V, Pathak GA, Koenen KC, Stein MB, Krystal JH, Pietrzak RH, Gelernter J, Goldfarb EV, Baron-Cohen S, Polimanti R. Polygenic scores for empathy associate with posttraumatic stress severity in response to certain traumatic events. Neurobiology Of Stress 2022, 17: 100439. PMID: 35242894, PMCID: PMC8881478, DOI: 10.1016/j.ynstr.2022.100439.Peer-Reviewed Original ResearchPosttraumatic stress disorderTraumatic eventsPolygenic scoringGreater emotional sensitivityChildhood neglect/abusePTSD symptom severityCertain traumatic eventsSevere PTSD symptomsPosttraumatic stress severityContext of traumaNeglect/abuseEarly life adversityHigher empathyPTSD symptomsEmotional sensitivityHigh empathizersStress disorderLife eventsEmpathyPotential traumaSymptom severityPolygenic scoresAutismStress severityDepression
2013
Childhood adversity moderates the effect of ADH1B on risk for alcohol‐related phenotypes in Jewish Israeli drinkers
Meyers JL, Shmulewitz D, Wall MM, Keyes KM, Aharonovich E, Spivak B, Weizman A, Frisch A, Edenberg HJ, Gelernter J, Grant BF, Hasin D. Childhood adversity moderates the effect of ADH1B on risk for alcohol‐related phenotypes in Jewish Israeli drinkers. Addiction Biology 2013, 20: 205-214. PMID: 24164917, PMCID: PMC3999313, DOI: 10.1111/adb.12102.Peer-Reviewed Original ResearchConceptsADH1B rs1229984Childhood adversityAUD severityAlcohol consumptionHeavy alcohol consumptionEnvironmental risk factorsAdult household residentsEarly life adversityMaximum drinksAUD symptom severityRisk factorsAlcohol metabolismSymptom severityLife adversityAlcohol-related phenotypesSeverityDisorder severityGenetic vulnerability
2010
Early-life stress, corticotropin-releasing factor, and serotonin transporter gene: A pilot study
Coplan JD, Abdallah CG, Kaufman J, Gelernter J, Smith EL, Perera TD, Dwork AJ, Kaffman A, Gorman JM, Rosenblum LA, Owens MJ, Nemeroff CB. Early-life stress, corticotropin-releasing factor, and serotonin transporter gene: A pilot study. Psychoneuroendocrinology 2010, 36: 289-293. PMID: 20692103, PMCID: PMC3017732, DOI: 10.1016/j.psyneuen.2010.07.011.Peer-Reviewed Original ResearchConceptsEarly life stressCSF CRF concentrationsCRF concentrationsCerebrospinal fluid corticotropin-releasing factor concentrationsCorticotropin-releasing factor concentrationsPilot studyNonhuman primate modelCorticotropin-releasing factorYears of ageEarly life adversitySerotonin transporter gene polymorphismPersistent elevationTransporter gene polymorphismPrimate modelMajor depressionCSF samplesDepressive symptomsGene polymorphismsAllele groupFactor concentrationsLFD conditionsMale bonnet macaquesChildhood abuseSubsequent developmentBonnet macaques