Featured Publications
Understanding the comorbidity between posttraumatic stress severity and coronary artery disease using genome-wide information and electronic health records
Polimanti R, Wendt FR, Pathak GA, Tylee DS, Tcheandjieu C, Hilliard AT, Levey DF, Adhikari K, Gaziano JM, O’Donnell C, Assimes TL, Stein MB, Gelernter J. Understanding the comorbidity between posttraumatic stress severity and coronary artery disease using genome-wide information and electronic health records. Molecular Psychiatry 2022, 27: 3961-3969. PMID: 35986173, PMCID: PMC10986859, DOI: 10.1038/s41380-022-01735-z.Peer-Reviewed Original ResearchConceptsCoronary artery diseasePosttraumatic stress disorderElectronic health recordsMillion Veteran ProgramArtery diseaseTotal scoreCAD diagnosisPlatelet amyloid precursor proteinHealth recordsPosttraumatic stress severityAmyloid precursor proteinEarly CAD diagnosisUK BiobankBidirectional relationshipTwo-sample Mendelian randomization (MR) analysisMendelian randomization analysisCAD riskHigh morbidityPTSD symptom severityCARDIoGRAMplusC4D consortiumPleiotropic mechanismsSymptom severityLongitudinal changesDiscordant effectsStress disorder
2020
Horizontal and Vertical Pleiotropy Linking Coronary Artery Disease, Traumatic Experiences, and Posttraumatic Stress in >650,000 Individuals
Polimanti R, Wendt F, Tcheandjieu C, Hilliard A, Levey D, Cheng Z, O’Donnell C, Stein M, Assimes T, Gelernter J. Horizontal and Vertical Pleiotropy Linking Coronary Artery Disease, Traumatic Experiences, and Posttraumatic Stress in >650,000 Individuals. Biological Psychiatry 2020, 87: s52-s53. DOI: 10.1016/j.biopsych.2020.02.158.Peer-Reviewed Original ResearchCoronary artery disease