Dopamine Beta‐Hydroxylase (DBH) gene and schizophrenia phenotypic variability: A genetic association study
Yamamoto K, Cubells JF, Gelernter J, Benkelfat C, Lalonde P, Bloom D, Lal S, Labelle A, Turecki G, Rouleau GA, Joober R. Dopamine Beta‐Hydroxylase (DBH) gene and schizophrenia phenotypic variability: A genetic association study. American Journal Of Medical Genetics Part B Neuropsychiatric Genetics 2002, 117B: 33-38. PMID: 12555232, DOI: 10.1002/ajmg.b.10011.Peer-Reviewed Original ResearchConceptsTherapeutic responseDopamine beta-hydroxylase (DBH) geneMean total BPRS scoreBeta-hydroxylase geneGroup of patientsTotal BPRS scoreLow DBH activityNR patientsBPRS scoresNeuroleptic drugsHealthy volunteersPsychotic symptomsSchizophrenic patientsDBH activitySymptom profilesPositive linkage disequilibriumPatientsCocaine-induced paranoiaCausative factorsPhenotypic variabilitySchizophreniaGenetic association studiesGenotype differencesPolymorphismDBH gene