2016
Genetic Relationship between Schizophrenia and Nicotine Dependence
Chen J, Bacanu SA, Yu H, Zhao Z, Jia P, Kendler KS, Kranzler HR, Gelernter J, Farrer L, Minica C, Pool R, Milaneschi Y, Boomsma DI, Penninx BW, Tyndale RF, Ware JJ, Vink JM, Kaprio J, Munafò M, Chen X. Genetic Relationship between Schizophrenia and Nicotine Dependence. Scientific Reports 2016, 6: 25671. PMID: 27164557, PMCID: PMC4862382, DOI: 10.1038/srep25671.Peer-Reviewed Original ResearchConceptsNeuroactive ligand-receptor interaction pathwayGenetic relationshipsEnergy production genesProtein modification genesLong non-coding RNAsNon-coding RNAsMultiple long non-coding RNAsProduction genesModification genesProtein geneInteraction pathwayGenesCalcium signalingP-value thresholdCritical roleRNANeuronal plasticityDifferent hypothesesFurther analysisLong-term potentiationSummary statisticsSignalingTraitsPathwayPlasticity
2013
Genome-Wide Association Study of Opioid Dependence: Multiple Associations Mapped to Calcium and Potassium Pathways
Gelernter J, Kranzler HR, Sherva R, Koesterer R, Almasy L, Zhao H, Farrer LA. Genome-Wide Association Study of Opioid Dependence: Multiple Associations Mapped to Calcium and Potassium Pathways. Biological Psychiatry 2013, 76: 66-74. PMID: 24143882, PMCID: PMC3992201, DOI: 10.1016/j.biopsych.2013.08.034.Peer-Reviewed Original ResearchMeSH KeywordsAllelesBlack or African AmericanCalcium ChannelsCalcium SignalingDatabases, GeneticGenetic Predisposition to DiseaseGenome-Wide Association StudyGenotypeHumansLong-Term PotentiationOpioid-Related DisordersPolymorphism, Single NucleotidePotassiumPotassium Channels, Voltage-GatedSignal TransductionWhite PeopleConceptsGenome-wide association studiesSingle nucleotide polymorphismsAssociation studiesSignificant single nucleotide polymorphismsGenomes reference panelGWAS dataMultiple lociPathway analysisCalcium signalingRisk variantsGenesNucleotide polymorphismsPotassium pathwaysSimilar pathwaysReference panelAdditional genotypesPathwayMost significant resultsMultiple associationsLong-term potentiationLociGeneticsSignalingRisk pathwaysMicroarray