2010
Early-life stress, corticotropin-releasing factor, and serotonin transporter gene: A pilot study
Coplan JD, Abdallah CG, Kaufman J, Gelernter J, Smith EL, Perera TD, Dwork AJ, Kaffman A, Gorman JM, Rosenblum LA, Owens MJ, Nemeroff CB. Early-life stress, corticotropin-releasing factor, and serotonin transporter gene: A pilot study. Psychoneuroendocrinology 2010, 36: 289-293. PMID: 20692103, PMCID: PMC3017732, DOI: 10.1016/j.psyneuen.2010.07.011.Peer-Reviewed Original ResearchConceptsEarly life stressCSF CRF concentrationsCRF concentrationsCerebrospinal fluid corticotropin-releasing factor concentrationsCorticotropin-releasing factor concentrationsPilot studyNonhuman primate modelCorticotropin-releasing factorYears of ageEarly life adversitySerotonin transporter gene polymorphismPersistent elevationTransporter gene polymorphismPrimate modelMajor depressionCSF samplesDepressive symptomsGene polymorphismsAllele groupFactor concentrationsLFD conditionsMale bonnet macaquesChildhood abuseSubsequent developmentBonnet macaques
1989
Intravenous physostigmine increases cerebrospinal fluid neuropeptide-Y
Berrettini W, Garrick N, Nurnberger J, Simmons-Alling S, Gelernter J, Gold P, Rubinow D, Murphy D. Intravenous physostigmine increases cerebrospinal fluid neuropeptide-Y. Biological Psychiatry 1989, 26: 623-630. PMID: 2790099, DOI: 10.1016/0006-3223(89)90087-5.Peer-Reviewed Original ResearchConceptsIntravenous infusionMicrograms/Central nervous system neurotransmittersAcute pharmacological challengePharmacological challenge paradigmsAcute intravenous infusionSerial CSF samplesDose-time interactionUseful clinical toolNormal human subjectsCholinergic agonist physostigmineCerebrospinal fluid neuropeptidesCSF NPYPhysostigmine infusionStimulus-induced responsesIntravenous physostigmineCSF levelsCSF cathetersCSF neuropeptidesNeuropeptide changesPharmacological challengeCSF samplesClinical toolRhesus monkeysPhysostigmine