2014
Nf1 Regulates Alcohol Dependence-Associated Excessive Drinking and Gamma-Aminobutyric Acid Release in the Central Amygdala in Mice and Is Associated with Alcohol Dependence in Humans
Repunte-Canonigo V, Herman MA, Kawamura T, Kranzler HR, Sherva R, Gelernter J, Farrer LA, Roberto M, Sanna PP. Nf1 Regulates Alcohol Dependence-Associated Excessive Drinking and Gamma-Aminobutyric Acid Release in the Central Amygdala in Mice and Is Associated with Alcohol Dependence in Humans. Biological Psychiatry 2014, 77: 870-879. PMID: 25483400, PMCID: PMC4428692, DOI: 10.1016/j.biopsych.2014.07.031.Peer-Reviewed Original ResearchConceptsChronic intermittent ethanol vapor exposureGABA releaseWild-type miceGamma-aminobutyric acidAlcohol dependenceCentral amygdalaGamma-aminobutyric acid releaseIntermittent ethanol vapor exposureExcessive drinkingMouse central amygdalaEthanol vapor exposureHeterozygous null miceAlcohol dependence riskInduction of dependenceAlcohol drinkingAlcohol-related behaviorsDependent drinkingBinge drinkingTranslational investigationsNull miceCentral nucleusType 1 geneMiceAmygdalaAcid release
2005
Apolipoprotein E epsilon4 is associated with atrophy of the amygdala in Alzheimer's disease
Basso M, Gelernter J, Yang J, MacAvoy MG, Varma P, Bronen RA, van Dyck CH. Apolipoprotein E epsilon4 is associated with atrophy of the amygdala in Alzheimer's disease. Neurobiology Of Aging 2005, 27: 1416-1424. PMID: 16182410, DOI: 10.1016/j.neurobiolaging.2005.08.002.Peer-Reviewed Original ResearchConceptsAlzheimer's diseaseAD patientsAPOE epsilon4AD groupImportant genetic risk factorApolipoprotein E epsilon4Regional brain atrophyAPOE epsilon4 alleleElderly control subjectsNormal elderly control subjectsGenetic risk factorsAmygdaloid volumesBrain atrophyControl subjectsEpsilon4 carriersRisk factorsEpsilon4 alleleHippocampal volumeEpsilon4 doseAnalysis of covarianceDisease severityPatientsEpsilon4AmygdalaAtrophy