2015
Optogenetic stimulation of cholinergic brainstem neurons during focal limbic seizures: Effects on cortical physiology
Furman M, Zhan Q, McCafferty C, Lerner BA, Motelow JE, Meng J, Ma C, Buchanan GF, Witten IB, Deisseroth K, Cardin JA, Blumenfeld H. Optogenetic stimulation of cholinergic brainstem neurons during focal limbic seizures: Effects on cortical physiology. Epilepsia 2015, 56: e198-e202. PMID: 26530287, PMCID: PMC4679683, DOI: 10.1111/epi.13220.Peer-Reviewed Original ResearchConceptsFocal limbic seizuresLimbic seizuresCortical functionBrainstem neuronsCortical dysfunctionFocal temporal lobe seizuresOptogenetic stimulationCortical slow-wave activityDepressed cortical functionSubcortical cholinergic neuronsTemporal lobe seizuresLoss of consciousnessPedunculopontine tegmental nucleusAnesthetized rat modelSlow wave activityCortical gamma activitySleep-like stateCholinergic neuronsFocal seizuresArousal networkCholinergic stimulationTegmental nucleusRat modelCortical physiologySeizuresArousal and Locomotion Make Distinct Contributions to Cortical Activity Patterns and Visual Encoding
Vinck M, Batista-Brito R, Knoblich U, Cardin JA. Arousal and Locomotion Make Distinct Contributions to Cortical Activity Patterns and Visual Encoding. Neuron 2015, 86: 740-754. PMID: 25892300, PMCID: PMC4425590, DOI: 10.1016/j.neuron.2015.03.028.Peer-Reviewed Original ResearchConceptsSensory-evoked cortical activityCortical activity patternsLocomotion effectsMouse V1Spontaneous firingLocal field potentialsCortical circuitsCortical activityRunning wheelArea V1Visual responsesPatterns of activityPupil diameterPopulation activityField potentialsMotor feedbackArousalV1Activity patternsArousal levelTemporal patterningComplementary roleMiceActivity
2011
A critical role for NMDA receptors in parvalbumin interneurons for gamma rhythm induction and behavior
Carlén M, Meletis K, Siegle J, Cardin J, Futai K, Vierling-Claassen D, Rühlmann C, Jones S, Deisseroth K, Sheng M, Moore C, Tsai L. A critical role for NMDA receptors in parvalbumin interneurons for gamma rhythm induction and behavior. Molecular Psychiatry 2011, 17: 537-548. PMID: 21468034, PMCID: PMC3335079, DOI: 10.1038/mp.2011.31.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAssociation LearningBrain WavesConditioning, PsychologicalExcitatory Postsynaptic PotentialsGABA AntagonistsGABAergic NeuronsInterneuronsMaleMaze LearningMemory, Short-TermMiceMice, TransgenicParvalbuminsPhotic StimulationPicrotoxinReceptors, N-Methyl-D-AspartateSensory GatingStereotyped BehaviorConceptsGamma oscillationsSpecific cognitive behaviorSelective cognitive impairmentsGamma rhythmsPsychosis-like symptomsCognitive tasksAssociative learningNeural network dysfunctionCognitive behaviorCortical gamma rhythmsCognitive impairmentNetwork dysfunctionNMDAR neurotransmissionOptogenetic drivePV interneuronsParvalbumin interneuronsNMDAR antagonistsMemoryReduced sensitivityBehaviorTaskHabituationDeficitsNormal behaviorLearning