2023
VIP interneurons regulate cortical size tuning and visual perception
Ferguson K, Salameh J, Alba C, Selwyn H, Barnes C, Lohani S, Cardin J. VIP interneurons regulate cortical size tuning and visual perception. Cell Reports 2023, 42: 113088. PMID: 37682710, PMCID: PMC10618959, DOI: 10.1016/j.celrep.2023.113088.Peer-Reviewed Original ResearchConceptsState-dependent modulationPyramidal neuronsVIP-INsBehavioral state-dependent modulationCortical circuit functionVasoactive intestinal peptidePrimary visual cortexAwake behaving miceIntestinal peptideGABAergic interneuronsVIP interneuronsCortical activityVisual cortexBehaving miceFeature selectivityInterneuronsSensory processingSpecialized populationCircuit functionStimulus sizeActivity altersDiverse populationsModulationPopulationCortexPutting the brakes on synchrony: VIP interneurons tune visually evoked rhythmic activity
Perrenoud Q, Cardin J. Putting the brakes on synchrony: VIP interneurons tune visually evoked rhythmic activity. Neuron 2023, 111: 297-299. PMID: 36731427, DOI: 10.1016/j.neuron.2023.01.004.Peer-Reviewed Original Research
2016
Projection-Specific Visual Feature Encoding by Layer 5 Cortical Subnetworks
Lur G, Vinck MA, Tang L, Cardin JA, Higley MJ. Projection-Specific Visual Feature Encoding by Layer 5 Cortical Subnetworks. Cell Reports 2016, 14: 2538-2545. PMID: 26972011, PMCID: PMC4805451, DOI: 10.1016/j.celrep.2016.02.050.Peer-Reviewed Original ResearchConceptsNeocortical sensory areasVisual response propertiesPrimary visual cortexVivo calcium imagingDownstream targetsCorticocortical cellsCorticostriatal cellsProjection neuronsRelevant downstream targetsCorticotectal cellsAfferent informationCortical subnetworksCC cellsVisual cortexCalcium imagingSensory areasSubcortical structuresLayer 5CT cellsDistinct subpopulationsSensory informationBroad tuningResponse propertiesCellsFunctional subnetworks
2011
A cell-type-specific dynamic Bayesian network model for spontaneous and optogenetically evoked activity in the primary visual cortex
Mohebi A, Cardin J, Oweiss K. A cell-type-specific dynamic Bayesian network model for spontaneous and optogenetically evoked activity in the primary visual cortex. BMC Neuroscience 2011, 12: o5. PMCID: PMC3240184, DOI: 10.1186/1471-2202-12-s1-o5.Peer-Reviewed Original Research
2010
Cellular Mechanisms of Temporal Sensitivity in Visual Cortex Neurons
Cardin JA, Kumbhani RD, Contreras D, Palmer LA. Cellular Mechanisms of Temporal Sensitivity in Visual Cortex Neurons. Journal Of Neuroscience 2010, 30: 3652-3662. PMID: 20219999, PMCID: PMC2880457, DOI: 10.1523/jneurosci.5279-09.2010.Peer-Reviewed Original ResearchConceptsLayer 4 neuronsCortical neuronsSensory-evoked synaptic inputsVisual cortex neuronsCellular mechanismsPrimary visual cortexCortex neuronsInhibitory interneuronsCortical functionExcitatory neuronsSynaptic inputsMembrane potential responsesSpike precisionVisual cortexCortical layersExcitatory conductanceNeuronsCoincident inputsInput integrationSynchronous inputsCortexNonlinear summationTemporal sensitivityAcuityInterneurons
2008
Cellular Mechanisms Underlying Stimulus-Dependent Gain Modulation in Primary Visual Cortex Neurons In Vivo
Cardin JA, Palmer LA, Contreras D. Cellular Mechanisms Underlying Stimulus-Dependent Gain Modulation in Primary Visual Cortex Neurons In Vivo. Neuron 2008, 59: 150-160. PMID: 18614036, PMCID: PMC2504695, DOI: 10.1016/j.neuron.2008.05.002.Peer-Reviewed Original ResearchConceptsSynaptic activationPrimary visual cortex neuronsCat primary visual cortexVisual cortex neuronsCellular mechanismsPrimary visual cortexNeuronal gainBackground synaptic activityVisual stimuliPostsynaptic effectsCortex neuronsIntracellular recordingsSynaptic activitySynaptic inputsVisual cortexInput resistanceVisual stimulationGain modulationSustained changesVivoSensory contextMembrane potentialNeuronal phenomenaActivationModulation
2007
Stimulus Feature Selectivity in Excitatory and Inhibitory Neurons in Primary Visual Cortex
Cardin JA, Palmer LA, Contreras D. Stimulus Feature Selectivity in Excitatory and Inhibitory Neurons in Primary Visual Cortex. Journal Of Neuroscience 2007, 27: 10333-10344. PMID: 17898205, PMCID: PMC3025280, DOI: 10.1523/jneurosci.1692-07.2007.Peer-Reviewed Original ResearchConceptsPrimary visual cortexFS cellsVisual cortexRS cellsLayer 4Feature selectivityThalamorecipient layer 4Cortical sensory processingResponses of excitatorySynaptic responsesInhibitory neuronsSynaptic inputsSynaptic integrationInhibitory cellsMembrane potential fluctuationsStimulus selectivitySpike outputLow input resistanceFiring rateSpike tuningType-specific differencesInput resistanceSpiking cellsCell type-specific differencesRegular spiking