1996
GABAA-receptor-mediated conductance and action potential waveform in cutaneous and muscle afferent neurons of the adult rat: differential expression and response to nerve injury
Oyelese A, Kocsis J. GABAA-receptor-mediated conductance and action potential waveform in cutaneous and muscle afferent neurons of the adult rat: differential expression and response to nerve injury. Journal Of Neurophysiology 1996, 76: 2383-2392. PMID: 8899611, PMCID: PMC2605353, DOI: 10.1152/jn.1996.76.4.2383.Peer-Reviewed Original ResearchConceptsGABAA receptor-mediated conductanceMuscle afferent neuronsCutaneous afferent neuronsAction potential waveformAfferent neuronsDorsal root gangliaCrush injuryAction potentialsL5 dorsal root gangliaWhole-cell patch-clamp recordingsCell patch-clamp recordingsInjury-induced plasticitySciatic nerve ligationPotential waveformDistal nerve stumpPatch-clamp recordingsGamma-aminobutyric acidPeak GABANerve ligationMuscle afferentsNerve injuryDRG neuronsInjured neuronsNerve stumpRoot ganglia
1995
Gabapentin potentiates the conductance increase induced by nipecotic acid in CA1 pyramidal neurons in vitro
Honmou O, Kocsis J, Richerson G. Gabapentin potentiates the conductance increase induced by nipecotic acid in CA1 pyramidal neurons in vitro. Epilepsy Research 1995, 20: 193-202. PMID: 7796791, DOI: 10.1016/0920-1211(94)00076-9.Peer-Reviewed Original ResearchConceptsRelease of GABACA1 pyramidal neuronsNipecotic acidPyramidal neuronsGABAA receptorsWhole-cell patch-clamp recordingsGABA uptake systemRat optic nerveCalcium-free solutionPeriod of hyperexcitabilityPatch-clamp recordingsChloride equilibrium potentialMechanism of actionGabapentin exposurePartial seizuresPressure microejectionOptic nerveAnticonvulsant gabapentinNonvesicular releaseHippocampal slicesNeuronal inhibitionMetabolic effectsSynaptic transmissionWhole-cell conductanceClamp recordings
1994
Retinal ganglion cells express a cGMP-gated cation conductance activatable by nitric oxide donors
Ahmad I, Leinders-Zufall T, Kocsis J, Shepherd G, Zufall F, Barnstable C. Retinal ganglion cells express a cGMP-gated cation conductance activatable by nitric oxide donors. Neuron 1994, 12: 155-165. PMID: 7507337, DOI: 10.1016/0896-6273(94)90160-0.Peer-Reviewed Original ResearchMeSH Keywords1-Methyl-3-isobutylxanthine8-Bromo Cyclic Adenosine MonophosphateAnimalsAnimals, NewbornBase SequenceCells, CulturedCyclic GMPCyclic Nucleotide-Gated Cation ChannelsCysteineDNA PrimersElectric ConductivityGene ExpressionIn Situ HybridizationIon ChannelsMembrane PotentialsModels, NeurologicalMolecular Sequence DataNitric OxideNitroprussidePolymerase Chain ReactionRatsRats, WistarRetinal Ganglion CellsRetinal Rod Photoreceptor CellsS-NitrosothiolsTranscription, GeneticConceptsRetinal ganglion cellsGanglion cellsWhole-cell patch-clamp recordingsRat retinal ganglion cellsNitric oxide donor sodium nitroprussideCation channelsGanglion cell activityPatch-clamp recordingsCation conductanceNitric oxide donorDonor sodium nitroprussideNonselective cation channelsAmacrine cellsSodium nitroprussideOxide donorPhosphodiesterase inhibitorCell activityPolymerase chain reaction amplificationNitric oxideChain reaction amplificationReversal potentialOutward rectificationRod photoreceptorsCGMPS-nitrosocysteine
1983
Effects of 4-aminopyridine on rapidly and slowly conducting axons of rat corpus callosum
Preston R, Waxman S, Kocsis J. Effects of 4-aminopyridine on rapidly and slowly conducting axons of rat corpus callosum. Experimental Neurology 1983, 79: 808-820. PMID: 6825765, DOI: 10.1016/0014-4886(83)90044-4.Peer-Reviewed Original ResearchMeSH Keywords4-AminopyridineAction PotentialsAminopyridinesAnimalsAxonsCorpus CallosumElectric ConductivityFemaleRatsRats, Inbred StrainsConceptsRat corpus callosumCallosal fibersCerebral axonsNerve fibersCorpus callosumMammalian peripheral nerve fibersNegative waveVoltage-dependent potassium currentsSecond negative waveNon-myelinated nerve fibresPeripheral nerve fibersField potentialsShort-latency wavesFirst negative waveCallosal stimulationPotassium blockersPotassium currentAction potentialsPeripheral fibersCallosumRecording electrodesMembrane repolarizationAxonsFunctional organizationComparable differences
1980
Absence of potassium conductance in central myelinated axons
Kocsis J, Waxman S. Absence of potassium conductance in central myelinated axons. Nature 1980, 287: 348-349. PMID: 7421994, DOI: 10.1038/287348a0.Peer-Reviewed Original ResearchMeSH KeywordsAction PotentialsAminopyridinesAnimalsElectric ConductivityNerve Fibers, MyelinatedPotassiumRatsSpinal CordTetraethylammonium CompoundsConceptsCentral myelinated axonsMyelinated axonsAction potentialsPotassium conductanceDorsal column axonsVoltage-clamp experimentsLate outward currentOutward currentsAxonsSodium ion permeabilityLate increaseDepolarization phasePotassium permeabilityAxonal membraneRepolarizationMyelinInitial increaseVoltage-dependent changesSodium inactivationDemyelinationPrevious studiesModulation of Impulse Conduction Along the Axonal Tree
Swadlow H, Kocsis J, Waxman S. Modulation of Impulse Conduction Along the Axonal Tree. Annual Review Of Biophysics And Bioengineering 1980, 9: 143-179. PMID: 6994588, DOI: 10.1146/annurev.bb.09.060180.001043.Peer-Reviewed Original ResearchAction PotentialsAnimalsAxonsElectric ConductivityHumansNeural ConductionNeural InhibitionTime Factors