Reinforcement Learning during Adolescence in Rats
Afshar N, Keip AJ, Taylor JR, Lee D, Groman SM. Reinforcement Learning during Adolescence in Rats. Journal Of Neuroscience 2020, 40: 5857-5870. PMID: 32601244, PMCID: PMC7380962, DOI: 10.1523/jneurosci.0910-20.2020.Peer-Reviewed Original ResearchConceptsNovel behavioral protocolReversal-learning performanceAdaptive choice behaviorBehavioral protocolFemale Long-Evans ratsReversal performanceChoice behaviorLong-Evans ratsAdolescent brain functionAge-related improvementsReinforcement-learning mechanismsReversal-learning taskReversal-learning paradigmDecision-making paradigmReinforcement learning mechanismAdolescent ratsLongitudinal designAge-related changesNeurodevelopmental mechanismsAdolescencePositive outcomesBrain functionFunction of circuitsPostnatal day 30AdulthoodUnlocking the Reinforcement-Learning Circuits of the Orbitofrontal Cortex
Groman SM, Lee D, Taylor JR. Unlocking the Reinforcement-Learning Circuits of the Orbitofrontal Cortex. Behavioral Neuroscience 2021, 135: 120-128. PMID: 34060870, PMCID: PMC8201418, DOI: 10.1037/bne0000414.Peer-Reviewed Original ResearchConceptsOrbitofrontal cortexReinforcement-learning mechanismsDecision-making impairmentsDiverse clinical populationsDecision-making differsNeurocomputational approachOFC dysfunctionNeuroscience techniquesBiobehavioral disordersBehavioral paradigmsClinical populationsBiobehavioral mechanismsAddiction pathologyComputational differencesReinforcement-learning algorithms